Dynamin I Antibody (3G4B6): sc-53877
- Dynamin I Antibody (3G4B6) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against purified truncated recombinant Dynamin I of human origin
- recommended for detection of Dynamin I of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Dynamin I Antibody (3G4B6) for WB applications. These reagents are now offered in bundles with Dynamin I Antibody (3G4B6) (see ordering information below).
QUICK LINKS
Dynamin I Antibody (3G4B6) is a mouse monoclonal IgG2a antibody that detects Dynamin I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Dynamin I plays a crucial role in the process of endocytosis, which is essential for cellular communication and nutrient uptake, particularly in the central nervous system where Dynamin I is predominantly localized. Dynamin I is vital for synaptic transmission and neurogenesis, as Dynamin I facilitates the fission of vesicles from the plasma membrane, allowing neurotransmitters to be released and recycled efficiently. The structure of Dynamin I includes SH3 and proline-rich domains that are instrumental in mediating interactions with various effectors, such as amphiphysin, which is highly expressed in the brain and is critical for the recruitment of Dynamin I to clathrin-coated pits. These interactions are necessary for the rapid endocytosis that underpins effective synaptic function. Anti-Dynamin I antibody (3G4B6) is an invaluable tool for researchers studying the dynamics of synaptic activity and the underlying mechanisms of neurogenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dynamin I Antibody (3G4B6) References:
- Inositol hexakisphosphate promotes dynamin I- mediated endocytosis. | Høy, M., et al. 2002. Proc Natl Acad Sci U S A. 99: 6773-7. PMID: 12011438
- Interaction of SPIN90 with dynamin I and its participation in synaptic vesicle endocytosis. | Kim, Y., et al. 2005. J Neurosci. 25: 9515-23. PMID: 16221862
- Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins. | Hill, T., et al. 2005. J Med Chem. 48: 7781-8. PMID: 16302817
- Rapid purification of native dynamin I and colorimetric GTPase assay. | Quan, A. and Robinson, PJ. 2005. Methods Enzymol. 404: 556-69. PMID: 16413300
- Age- and experience-dependent expression of dynamin I and synaptotagmin I in cat visual system. | Cnops, L., et al. 2007. J Comp Neurol. 504: 254-64. PMID: 17640048
- Dynamin I plays dual roles in the activity-dependent shift in exocytic mode in mouse adrenal chromaffin cells. | Fulop, T., et al. 2008. Arch Biochem Biophys. 477: 146-54. PMID: 18492483
- Some selective serotonin reuptake inhibitors inhibit dynamin I guanosine triphosphatase (GTPase). | Otomo, M., et al. 2008. Biol Pharm Bull. 31: 1489-95. PMID: 18670077
- The pthaladyns: GTP competitive inhibitors of dynamin I and II GTPase derived from virtual screening. | Odell, LR., et al. 2010. J Med Chem. 53: 5267-80. PMID: 20575553
- Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I. | Tian, Q., et al. 2012. Neurosci Bull. 28: 483-92. PMID: 22961472
- Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. | Cossar, PJ., et al. 2023. Eur J Med Chem. 247: 115001. PMID: 36577213
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dynamin I Antibody (3G4B6) | sc-53877 | 200 µg/ml | $322.00 | |||
Dynamin I Antibody (3G4B6): m-IgG Fc BP-HRP Bundle | sc-539010 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dynamin I Antibody (3G4B6): m-IgG2a BP-HRP Bundle | sc-546660 | 200 µg Ab; 10 µg BP | $361.00 |