Anticorps DAP-3 (4H75): sc-70949
- L'anticorps DAP-3 4H75 est un monoclonal IgG1 de souris fourni en 100 µg/ml
- soulevée à l'encontre des acides aminés 45-52 and 358-371 et 358-371 de DAP-3 d'origine human.
- recommandé pour la détection de DAP-3 d'origine mouse, rat et human par WB et IP
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire DAP-3 (4H75). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
The death-associated protein 3 (DAP-3), is a nucleotide-binding protein that contains a potential P-loop motif. It is a positive mediator of programmed cell death; overexpressed intact full-length protein is required in order to induce apoptosis. DAP-3 functions downstream of its receptor signaling complex and its death promoting effects depend on caspase activity. It also interacts with the glucocorticoid receptor (GR), where its main interaction domain is the amino-terminal region, which acts in a dominant-negative fashion to protect cells from apoptosis. DAP-3 protein may also play a role in modulating the cytoplasmic GR/HSP 90 complex. It is conserved at the functional, as well as the structural level, and is ubiquitously expressed in highly proliferative epithelial compartments of various tissues. Unlike a number of other proteins, DAP-3 retains its mitochondrial localization during the induction of apoptosis.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps DAP-3 (4H75) | sc-70949 | 100 µg/ml | $316.00 |