ACCÈS RAPIDE AUX LIENS
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism iscaused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps CYP11B1 (B-11) | sc-377248 | 200 µg/ml | $316.00 | |||
CYP11B1 (B-11): m-IgG Fc BP-HRP Kit | sc-538029 | 200 µg Ab; 10 µg BP | $354.00 | |||
CYP11B1 (B-11): m-IgGκ BP-HRP Kit | sc-535550 | 200 µg Ab; 40 µg BP | $354.00 | |||
CYP11B1 (B-11): m-IgG1 BP-HRP Kit | sc-545494 | 200 µg Ab; 20 µg BP | $354.00 | |||
CYP11B1 (B-11) peptide neutralisant | sc-377248 P | 100 µg/0.5 ml | $68.00 |