CTH Antibody (D-12): sc-365382
- CTH Antibody (D-12) is a mouse monoclonal IgG1 κ, cited in 12 publications, provided at 200 µg/ml
- raised against amino acids 61-227 mapping within an internal region of CTH of human origin
- recommended for detection of CTH isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See CTH (F-1): sc-374249 for CTH antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CTH Antibody (D-12) for WB and IHC(P) applications. These reagents are now offered in bundles with CTH Antibody (D-12) (see ordering information below).
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SEE ALSO...
CTH Antibody (D-12) is a mouse monoclonal IgG1 antibody that detects CTH in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CTH, or cystathionine γ-lyase, is a crucial enzyme in the trans-sulfuration pathway, primarily located in the cytoplasm where it catalyzes the β-disulfide elimination reaction dependent on pyridoxal phosphate, leading to the production of ammonium, pyruvate, and thiocysteine. The thiocysteine generated can subsequently react with other thiols, including cysteine, to produce hydrogen sulfide (H2S), which is vital for numerous cellular functions. H2S acts as a signaling molecule that regulates processes such as cell growth, hyperpolarization of cell membranes, modulation of neuronal excitability, and relaxation of smooth muscle cells, highlighting its importance in maintaining vascular health and overall cellular homeostasis. Furthermore, mutations in the CTH gene can lead to cystathioninuria, an autosomal recessive disorder characterized by the abnormal accumulation of cystathionine in plasma and increased urinary excretion, underscoring the clinical significance of this enzyme. Anti-CTH antibody (D-12) is an essential tool for researchers investigating the role of H2S in physiological and pathological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CTH Antibody (D-12) | sc-365382 | 200 µg/ml | $322.00 | |||
CTH Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-540334 | 200 µg Ab; 10 µg BP | $361.00 | |||
CTH Antibody (D-12): m-IgG1 BP-HRP Bundle | sc-542049 | 200 µg Ab; 20 µg BP | $361.00 |