CTH Antibody (A-2): sc-365381

CTH Antibody (A-2) is a mouse monoclonal IgG2a antibody that detects CTH in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CTH, or cystathionine γ-lyase, is a crucial enzyme in the trans-sulfuration pathway, primarily located in the cytoplasm, where CTH catalyzes the β-disulfide elimination reaction dependent on pyridoxal phosphate. This reaction produces ammonium, pyruvate, and thiocysteine, with the latter being a precursor for hydrogen sulfide (H2S) production. CTH′s cellular location is significant due to CTH′s role as the major H2S-producing enzyme in key tissues such as the kidney, liver, vascular smooth muscle cells, and enterocytes. The endogenous production of H2S is vital for regulating numerous cellular functions, including promoting cell growth, hyperpolarizing cell membranes, modulating neuronal excitability, and facilitating the relaxation of smooth muscle cells. Dysregulation or mutations in the CTH gene can lead to cystathioninuria, an autosomal recessive disorder characterized by the abnormal accumulation of cystathionine in plasma and increased urinary excretion, highlighting CTH′s importance in maintaining metabolic balance and cellular health. Anti-CTH antibody (A-2) is an essential tool for researchers investigating the physiological and pathological roles of this enzyme in various biological contexts.

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CTH Antibody (A-2) References:

1. Epigenetic Factors in Late-Onset Alzheimer's Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins.  |  Román, GC., et al. 2019. Int J Mol Sci. 20: PMID: 30646578
2. CTH/H2S Regulates LPS-Induced Inflammation through IL-8 Signaling in MAC-T Cells.  |  Lin, T., et al. 2022. Int J Mol Sci. 23: PMID: 36233122
3. CTH G1208T and MTHFR A1298C polymorphisms are associated with a higher risk of a first myocardial infarction with fatal outcome among women.  |  Söderström, E., et al. 2023. Drug Metab Pers Ther. 38: 57-63. PMID: 36279151
4. Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair.  |  Zhao, XH., et al. 2023. Cell Commun Signal. 21: 17. PMID: 36691021
5. CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway.  |  Katsouda, A., et al. 2023. Front Pharmacol. 14: 1090654. PMID: 36860295
6. Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation.  |  Peleli, M., et al. 2023. Redox Biol. 64: 102773. PMID: 37300955
7. NOS3 and CTH gene mutations as new molecular markers for detection of lung adenocarcinoma.  |  Abdullah Ramadhan, I., et al. 2023. PeerJ. 11: e16209. PMID: 38107574
8. Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding.  |  Qu, H., et al. 2024. Sci Rep. 14: 4352. PMID: 38388661
9. CTH-Net: A CNN and Transformer hybrid network for skin lesion segmentation.  |  Ding, Y., et al. 2024. iScience. 27: 109442. PMID: 38523786
10. Cr(VI) induced hepatocyte apoptosis through the CTH/H2S/Drp1 signaling pathway.  |  Zhou, J., et al. 2024. Sci Total Environ. 950: 175332. PMID: 39117219

The preferred CTH antibody is CTH Antibody (F-1): sc-374249.