CtBP Antibody (B-3): sc-55502

CtBP Antibody (B-3) is a mouse monoclonal IgG2a antibody that detects CtBP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CtBP, or C-terminal binding protein, plays a crucial role as a transcriptional corepressor, influencing various cellular processes by modulating gene expression. anti-CtBP antibody (B-3) is particularly important for studying cellular development and differentiation, as CtBP interacts with a range of transcription factors to repress target genes. Notably, CtBP is involved in the regulation of the p21 promoter in response to DNA damage, a critical function that helps maintain genomic stability. The interaction between CtBP and CtIP, a protein that recognizes distinct motifs, is essential for this regulatory mechanism, as CtIP binds to the BRCT repeats of the breast cancer gene BRCA1, thereby enabling CtBP to influence BRCA1 activity. The ability of CtBP to form complexes with other proteins, such as δEF1, further underscores its significance in transcriptional silencing during skeletal and T-cell development. With versatile applications and vital role in cellular regulation, CtBP monoclonal antibody (B-3) serves as an invaluable tool for researchers studying gene expression and its implications in various biological processes.

The preferred CtBP antibody is CtBP Antibody (E-12): sc-17759.