CLEC-L1 Antibody (UW50): sc-293090

CLEC-L1 Antibody (UW50) is a mouse monoclonal IgM antibody that detects CLEC-L1 of human origin by western blotting (WB) and indirect applications. Anti-CLEC-L1 antibody (UW50) is available as a non-conjugated format. CLEC-L1, also known as DCAL-1 (dendritic cell-associated lectin 1), is a 167 amino acid single-pass type II membrane protein characterized by the presence of one C-type lectin domain. CLEC-L1 plays a crucial role in cell-to-cell immune interactions, particularly in enhancing immune response by acting as a costimulatory molecule that increases interleukin-4 production. CLEC-L1 is highly expressed in dendritic cells and B-cells, predominantly located in tonsil, lymph node, and spleen, with lower expression levels observed in peripheral blood and colon. CLEC-L1′s location in immune cells enables communication between immune cells, thereby influencing overall immune response. Encoded by a gene located on human chromosome 12p13.31, CLEC-L1 is part of the C-type lectin/C-type lectin-like domain superfamily, which encompasses proteins that share a common protein fold and are involved in diverse functions such as cell adhesion, glycoprotein turnover, and immune responses.

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CLEC-L1 Antibody (UW50) References:

1. C-type lectin-like domains.  |  Drickamer, K. 1999. Curr Opin Struct Biol. 9: 585-90. PMID: 10508765
2. Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells.  |  Arce, I., et al. 2001. Eur J Immunol. 31: 2733-40. PMID: 11536172
3. Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4.  |  Ryan, EJ., et al. 2002. J Immunol. 169: 5638-48. PMID: 12421943
4. Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.  |  Ebner, S., et al. 2003. Proteins. 53: 44-55. PMID: 12945048
5. The C-type lectin fold as an evolutionary solution for massive sequence variation.  |  McMahon, SA., et al. 2005. Nat Struct Mol Biol. 12: 886-92. PMID: 16170324
6. C-type lectins on dendritic cells and their interaction with pathogen-derived and endogenous glycoconjugates.  |  Gijzen, K., et al. 2006. Curr Protein Pept Sci. 7: 283-94. PMID: 16918443

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CLEC-L1 Antibody (UW50) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CLEC-L1 Antibody (UW50) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CLEC-L1 Antibody (UW50) Specifications

Alternate Product Name: CLEC-L1

Product Clone Name: UW50

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: CLEC-L1

Epitope Species: human

Product Reactivity/Detection: CLEC-L1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, indirect

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CLEC-L1 Antibody (UW50): N/A