Anticorps CLC-2 (YY9): sc-81871
- L'Anticorps CLC-2 (YY9) est un monoclonal de souris IgG2a κ, cité dans 1 publications, fourni en 50 µg/0.5 ml
- dirigé contre la CLC-2 recombinante d'origine human
- recommandé pour la détection de CLC-2 d'origine human par WB, IP et ELISA
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire CLC-2 (YY9). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7q32, 3q28, 4q32, Xp22.3, Xp11.23-p11.22, 1p36 and 16p13, respectively. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps CLC-2 (YY9) | sc-81871 | 50 µg/0.5 ml | $316.00 |