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The Wilms' tumor suppressor protein, WT1, contains a zinc finger domain and is capable of both activating or repressing transcription, depending on cell type and promotor context. A number of proteins, including various tumor suppressors, have been shown to interact with WT1. Interaction of WT1 with p53 results in increased p53 stability, and inhibits the ability of p53 to induce apoptosis. Par-4, a transcriptional repressor, is also known to bind WT1. Ciao 1, a member of the WD40 family of proteins, specifically interacts with WT1, resulting in a decrease in WT1 mediated transcriptional activation. Ciao 1 does not inhibit binding by causing a conforma-tional change or by interfering with the activation domain of WT1.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Ciao 1 (C-4) | sc-374499 | 200 µg/ml | $316.00 | |||
Ciao 1 (C-4): m-IgG Fc BP-HRP Kit | sc-540463 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ciao 1 (C-4): m-IgG2a BP-HRP Kit | sc-546909 | 200 µg Ab; 10 µg BP | $354.00 |