ACCÈS RAPIDE AUX LIENS
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase, the initial enzyme in the sequence, plays a role in cell growth proliferation. Hemicholinium-3 (HC-3), an inhibitor for Choline Kinase (also known as ChoK and CKI), drastically reduces entry into S phase after stimulation by growth factors. In Ras-transformed cells, an increased level of phosphorylcholine (PCho) results from the consecutive activation of phospholipase D (PLD) and ChoK. ChoK and its product, PCho, have been implicated in human carcinogenesis, including the development of human breast cancer, and ChoK dysregulation is found in a variety of human tumors such as lung, colorectal, and prostate tumors. The human Choline kinase gene maps to chromosome 11q13.2.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ChoK (B-6) | sc-390060 | 200 µg/ml | $316.00 | |||
ChoK (B-6): m-IgG Fc BP-HRP Kit | sc-538058 | 200 µg Ab; 10 µg BP | $354.00 | |||
ChoK (B-6): m-IgGκ BP-HRP Kit | sc-535585 | 200 µg Ab; 40 µg BP | $354.00 | |||
ChoK (B-6) peptide neutralisant | sc-390060 P | 100 µg/0.5 ml | $68.00 |