Chaetocin CAS: 28097-03-2
MF: C30H28N6O6S4
MW: 696.84
A lysine-specific histone methyltransferase inhibitor.

Chaetocin (CAS 28097-03-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
Synonyme: Methyltransferase inhibitor
Application: A lysine-specific histone methyltransferase inhibitor
Numéro CAS: 28097-03-2
Pureté: ≥98%
Masse Moléculaire: 696.84
Formule Moléculaire: C30H28N6O6S4
* Consulter le Certificat d'Analyses pour les données spécifiques à un lot (incluant la teneur en eau).
Postez un avis sur ce produit et recevez 15 CruzCredits

Chaetocin, a natural product originally produced by Chaetomium species, is shown to have apoptotic effects on some cancer cells. Mechanistic studies show that chaetocin is taken up in the cells by a process that requires intact/unreduced disulfides for uptake. Once inside, this compound imposes oxidative stress and consequent apoptosis induction. Other studies have shown chaetocin to reduce lysine-specific histone methyltransferase effects of SUV39H, which play a key role in maintaining stable gene expression patterns during embryonic development and cellular differentiation. Additionally, this agent is reported to cause profound chromatin reorganization in fibroblast nuclei by inducing chromatin condensation/clustering. Consequentially, chaetocin impairs Trx (thioredoxin) systems, which are essential for deoxynucleotide synthesis and involved in a broad range of cellular functions. Chaetocin is an inhibitor of G9a, SUV39H1 and TrxR1.


Références

1. Greiner, Dorothea., et al., 2005. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nature chemical biology. 1(3): 143-5. PMID: 16408017
2. Isham, Crescent R., et al., 2007. Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Blood. 109(6): 2579-88. PMID: 17090648
3. Illner, Doris., et al., 2010. Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin. Experimental cell research. 316(10): 1662-80. PMID: 20302859

État Physique :
Solid
Dérivé de :
Chaetomium
Solubilité :
Soluble in DMSO (~25 mg/ml), and ethanol (25 mg/ml).
STOCKAGE :
Store at -20° C
Densité :
~1.9 g/cm3 (Predicted)
Indice de Réfraction :
n20D 1.93
IC50 :
HeLa cells: IC50 = 0.05 µg/ml; HMT SU(VAR)3-9: IC50 = 0.6 µm (Drosophila melanogaster); ortholog: IC50 = 0.8 µm (human); HMT SU(VAR)3-9 : IC50 = 0.8 µm; G9a: IC50 = 2.5 µm; DIM5: IC50 = 3 µm; Lys9-HMTs: IC50 = >90 µm
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
WGK Allemagne :
3
RTECS :
FM3032000
PubChem CID :
11657687
Numéro MDL :
MFCD00133163
SMILES :
CN1C(=O)[[email protected]@]23C[[email protected]]4([[email protected]@H](N2C(=O)[[email protected]@]1(SS3)CO)NC5=CC=CC=C54)[[email protected]]67C[[email protected]]89C(=O)N([[email protected]](C(=O)N8[[email protected]]6NC1=CC=CC=C71)(SS9)CO)C

Télécharger la Fiche de Sécurité/ SDS (MSDS)

CERTIFICAT D'ANALYSE

Pour une bonne lecture, Adobe Acrobat Reader est requis,
imprimer et commenter les documents PDF

Chaetocin  Références bibliographiques

Consultez les publications faisant référence à l' utilisation de Chaetocin. Cliquez sur le lien pour afficher lentrée PubMed .

Citations 1 à 4 sur un total de 4

PMID: # 27141211  Rombo, R. et al. 2016. German medical science : GMS e-journal. 14: Doc04.

PMID: # 27924221  Liu, L. et al. 2016. Cell Discov. 2: 16036.

PMID: # 27467759  Das, S. et al. 2016. PLoS ONE. 11: e0160022.

PMID: # 31811153  Nat Commun. 10: 5594.

Citations 1 à 4 sur un total de 4
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 133ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 12ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. est leader mondial dans le développement de produits pour la recherche biomédicale. Contactez-nous au 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. Tous Droits Réservés. "Santa Cruz Biotechnology", et le logo Santa Cruz Biotechnology, Inc., "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", le logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", et "EZ Touch" sont des marques déposées de Santa Cruz Biotechnology, Inc.
Toutes les marques sont la propriété de leurs propriétaires respectifs.