CD27 Antibody (F-8): sc-390079
- CD27 Antibody (F-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 221-249 at the C-terminus of CD27 of mouse origin
- recommended for detection of CD27 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for CD27 Antibody (F-8) for WB applications. These reagents are now offered in bundles with CD27 Antibody (F-8) (see ordering information below).
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CD27 Antibody (F-8) is a mouse monoclonal IgG2a antibody that detects CD27 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD27 is a crucial member of the tumor necrosis factor receptor family, functioning as a homodimeric lymphocyte-specific surface antigen predominantly found on T and B lymphocytes. CD27 expression is significantly upregulated upon T cell receptor activation, which is vital for generating co-stimulatory signals necessary for complete T cell activation. This process is essential for an effective immune response, as CD27 interacts with CD27L to enhance T cell proliferation and survival. Additionally, CD27 plays a role in regulating the immune system′s balance, influencing both activation and apoptosis of lymphocytes. Understanding CD27 function and signaling pathways is important for developing therapeutic strategies in various diseases, including autoimmune disorders and cancers, where modulation of T cell responses can have significant clinical implications. Anti-CD27 antibody (F-8) is an invaluable tool for researchers investigating these critical immune mechanisms.
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CD27 Antibody (F-8) References:
- CD27/CD70 interactions regulate T dependent B cell differentiation. | Jacquot, S. 2000. Immunol Res. 21: 23-30. PMID: 10803880
- CD27 and CD70 in T cell and B cell activation. | Borst, J., et al. 2005. Curr Opin Immunol. 17: 275-81. PMID: 15886117
- Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer. | Bullock, TN. 2017. Curr Opin Immunol. 45: 82-88. PMID: 28319731
- CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion. | Deng, Y., et al. 2021. Blood. 137: 3225-3236. PMID: 33827115
- Dysfunction of CD27+IgD+ B cells correlates with aggravated systemic lupus erythematosus. | Zhang, W., et al. 2022. Clin Rheumatol. 41: 1551-1559. PMID: 35032222
- Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering. | Heckel, F., et al. 2022. Commun Biol. 5: 229. PMID: 35288635
- Plasma CD27, a Surrogate of the Intratumoral CD27-CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma. | Benhamouda, N., et al. 2022. Clin Cancer Res. 28: 4983-4994. PMID: 36067339
- CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response. | Cao, L., et al. 2023. Cell Transplant. 32: 9636897221149444. PMID: 36644879
- New Presentation of CD27 Deficiency; Coronary Ectasia and COVID-19. | Golchehre, Z., et al. 2023. Iran J Allergy Asthma Immunol. 22: 110-118. PMID: 37002625
- Differentiation and immunosuppressive function of CD19+CD24hiCD27+ regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway. | Li, JY., et al. 2024. Hepatobiliary Pancreat Dis Int. 23: 472-480. PMID: 38724321
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD27 Antibody (F-8) | sc-390079 | 200 µg/ml | $322.00 | |||
CD27 Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-540753 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD27 Antibody (F-8): m-IgG2a BP-HRP Bundle | sc-546952 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD27 (F-8) Neutralizing Peptide | sc-390079 P | 100 µg/0.5 ml | $69.00 |