CD2 Antibody (AT37): sc-13531
- CD2 Antibody (AT37) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against the extracellular domain of CD2 of mouse origin
- recommended for detection of CD2 of mouse and rat origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD2 Antibody (AT37). This work is in progress.
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CD2 Antibody (AT37) is a rat monoclonal IgG2a antibody that detects CD2 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2′s primary function is to mediate cell adhesion through interaction with the CD58 ligand, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, as CD2 facilitates communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores CD2′s potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (AT37) provides a reliable tool for researchers studying T cell activation and immune interactions, contributing to a deeper understanding of immune system dynamics.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD2 Antibody (AT37) References:
- CD2-associated protein directly interacts with the actin cytoskeleton. | Lehtonen, S., et al. 2002. Am J Physiol Renal Physiol. 283: F734-43. PMID: 12217865
- CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. | Kim, JM., et al. 2003. Science. 300: 1298-300. PMID: 12764198
- Clues to CD2-associated protein involvement in cytokinesis. | Monzo, P., et al. 2005. Mol Biol Cell. 16: 2891-902. PMID: 15800069
- Enhanced expression of CD2 antigen on lung T cells. | Yamaguchi, E., et al. 1991. Am Rev Respir Dis. 143: 829-33. PMID: 1672587
- Cd2+ as a Ca2+ surrogate in protein-membrane interactions: isostructural but not isofunctional. | Morales, KA., et al. 2013. J Am Chem Soc. 135: 12980-3. PMID: 23937054
- Glycosylation and Lipids Working in Concert Direct CD2 Ectodomain Orientation and Presentation. | Polley, A., et al. 2017. J Phys Chem Lett. 8: 1060-1066. PMID: 28191954
- Nurse-like cells promote CLL survival through LFA-3/CD2 interactions. | Boissard, F., et al. 2017. Oncotarget. 8: 52225-52236. PMID: 28881725
- Mutational analysis of the epitopes recognized by anti-(rat CD2) and anti-(rat CD48) monoclonal antibodies. | Davis, SJ., et al. 1995. Biochem Soc Trans. 23: 188-94. PMID: 7538945
- Binding of cadmium (Cd2+) to E-CAD1, a calcium-binding polypeptide analog of E-cadherin. | Prozialeck, WC., et al. 1996. Life Sci. 58: PL325-30. PMID: 8637391
- A cutaneous agranular CD2- CD4+ CD56+ 'lymphoma': report of two cases and review of the literature. | Kameoka, J., et al. 1998. Am J Clin Pathol. 110: 478-88. PMID: 9763034
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (AT37) | sc-13531 | 200 µg/ml | $322.00 | |||
CD2 Antibody (AT37) FITC | sc-13531 FITC | 200 µg/ml | $336.00 | |||
CD2 Antibody (AT37) PE | sc-13531 PE | 200 µg/ml | $349.00 |