CapZ-α Antibody (C-7): sc-376134

CapZ-α Antibody (C-7) is a mouse monoclonal IgG2a antibody that detects CapZ-α in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CapZ-α, also known as F-Actin-capping protein subunit alpha-1, is a crucial 286 amino acid component of the F-Actin capping protein complex, which plays a vital role in regulating actin dynamics by binding to the fast-growing barbed ends of actin filaments. This binding prevents the exchange of proteins at these ends, thereby stabilizing the actin filaments and facilitating the nucleation of actin monomers, which is essential for maintaining cellular structure and motility. The proper functioning of CapZ-α is particularly important in muscle contraction and cell movement, as CapZ-α ensures that actin filaments are appropriately assembled and disassembled in response to cellular signals. Additionally, CapZ-α has been shown to interact with the S-100 β chain, a signaling molecule involved in the calcium-sensitive assembly of intermediate filaments, linking CapZ-α to critical processes such as neuronal function and the pathogenesis of Alzheimer′s disease. With its ability to provide insights into actin dynamics and cellular signaling pathways, anti-CapZ-α antibody (C-7) is an invaluable tool for researchers studying cytoskeletal organization and related diseases.

The preferred CapZ-α antibody is CapZ-α Antibody (H-9): sc-374302.