Date published: 2026-7-23

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C6 Ceramide-13C2,d2

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Application:
C6 Ceramide-13C2,d2 is a ceramide analog that stimulates protein phosphatase 2A and activates MAP kinase
Purity:
98%
Molecular Weight:
401.63
Molecular Formula:
C2213C2H45D2NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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C6 Ceramide-13C2,d2 is a synthetically labeled variant of C6 ceramide, a short-chain ceramide molecule that plays a crucial role in cellular signaling and membrane dynamics. This particular molecule is isotopically labeled with carbon-13 (13C2) and deuterium (d2), enhancing its utility in scientific research, especially in studies involving stable isotope tracing and molecular dynamics. The isotopic labels allow researchers to monitor the molecule′s metabolism and interaction within biological systems using sensitive analytical techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. This enables a deeper understanding of lipid metabolism and the specific pathways through which ceramides exert their functions at a cellular level. C6 Ceramide-13C2,d2 is particularly valuable in the study of lipid rafts and the role of ceramides in the induction of biophysical changes within cellular membranes. Researchers employ this molecule to explain how ceramides influence membrane curvature, fluidity, and the formation of signaling platforms. By tracing the incorporation of isotopically labeled ceramides into various cellular components, scientists can gain insights into the temporal and spatial dynamics of ceramide function and its interactions with other lipids and proteins in the membrane.


C6 Ceramide-13C2,d2 References

  1. Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells.  |  Raines, MA., et al. 1993. J Biol Chem. 268: 14572-5. PMID: 7686898
  2. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.  |  Jarvis, WD., et al. 1994. Proc Natl Acad Sci U S A. 91: 73-7. PMID: 8278410
  3. Ceramide activates heterotrimeric protein phosphatase 2A.  |  Dobrowsky, RT., et al. 1993. J Biol Chem. 268: 15523-30. PMID: 8393446

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

C6 Ceramide-13C2,d2, 500 µg

sc-217814
500 µg
$583.00