Axotrophin Antibody (B-2): sc-166945
- Axotrophin Antibody (B-2) is a mouse monoclonal IgG2b κ Axotrophin antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 583-642 mapping near the C-terminus of Axotrophin of human origin
- Axotrophin Antibody (B-2) is recommended for detection of Axotrophin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Axotrophin Antibody (B-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Axotrophin Antibody (B-2) for WB and IHC(P) applications. This reagent is now offered in a bundle with Axotrophin Antibody (B-2) (see ordering information below).
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Axotrophin Antibody (B-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects Axotrophin protein in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Axotrophin antibody (B-2) comes in non-conjugated form and various conjugates, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® options. Axotrophin (B-2) antibody recognizes a protein crucial for T lymphocyte regulation, specifically in cell proliferation modulation and leukemia inhibitory factor (LIF) release - a neuropoietic cytokine essential for stem cell maintenance and thymocyte activation. Axotrophin monoclonal antibody (B-2) targets a protein that interacts with LIF in transplantation intolerance, highlighting their role in immune response and tissue compatibility. Axotrophin (B-2) monoclonal antibody identifies a protein involved in corpus callosum differentiation and sensory neuron survival in the substantia gelatinosa of adult spinal cord, particularly in a glial cell line-derived neurotrophic factor-dependent manner. Anti-Axotrophin antibody (B-2) detects expression predominantly in hippocampus, cortex, and cerebellar purkinje and granule cells, emphasizing Axotrophin′s importance in neurodevelopment and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Axotrophin Antibody (B-2) References:
- Transplantation tolerance: gene expression profiles comparing allotolerance vs. allorejection. | Metcalfe, SM. and De S Muthukumarana, PA. 2005. Int Immunopharmacol. 5: 33-9. PMID: 15589457
- Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. | Metcalfe, SM., et al. 2005. FEBS Lett. 579: 609-14. PMID: 15670816
- Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance. | Metcalfe, SM. 2005. Philos Trans R Soc Lond B Biol Sci. 360: 1687-94. PMID: 16147533
- Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. | Escary, JL., et al. 1993. Nature. 363: 361-4. PMID: 8497320
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Axotrophin Antibody (B-2) | sc-166945 | 200 µg/ml | $322.00 | |||
Axotrophin Antibody (B-2): m-IgG2b BP-HRP Bundle | sc-548687 | 200 µg Ab; 10 µg BP | $361.00 | |||
Axotrophin Antibody (B-2) AC | sc-166945 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Axotrophin Antibody (B-2) HRP | sc-166945 HRP | 200 µg/ml | $322.00 | |||
Axotrophin Antibody (B-2) FITC | sc-166945 FITC | 200 µg/ml | $336.00 | |||
Axotrophin Antibody (B-2) PE | sc-166945 PE | 200 µg/ml | $349.00 | |||
Axotrophin Antibody (B-2) Alexa Fluor® 488 | sc-166945 AF488 | 200 µg/ml | $364.00 | |||
Axotrophin Antibody (B-2) Alexa Fluor® 546 | sc-166945 AF546 | 200 µg/ml | $364.00 | |||
Axotrophin Antibody (B-2) Alexa Fluor® 594 | sc-166945 AF594 | 200 µg/ml | $364.00 | |||
Axotrophin Antibody (B-2) Alexa Fluor® 647 | sc-166945 AF647 | 200 µg/ml | $364.00 | |||
Axotrophin Antibody (B-2) Alexa Fluor® 680 | sc-166945 AF680 | 200 µg/ml | $364.00 | |||
Axotrophin Antibody (B-2) Alexa Fluor® 790 | sc-166945 AF790 | 200 µg/ml | $364.00 |