Atlastin Antibody (E-9): sc-376619
- Atlastin Antibody (E-9) is a mouse monoclonal IgG1 (lambda light chain) provided at 200 µg/ml
- specific for an epitope mapping between amino acids 525-550 at the C-terminus of Atlastin of human origin
- recommended for detection of Atlastin of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Atlastin Antibody (E-9) for WB applications. These reagents are now offered in bundles with Atlastin Antibody (E-9) (see ordering information below).
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SEE ALSO...
Atlastin Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects Atlastin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Atlastin is a crucial Golgi-localized integral membrane protein that functions as a GTPase, playing a significant role in maintaining axonal integrity. Atlastin′s importance is underscored by involvement in hereditary spastic paraplegia (HSP), a neurodegenerative disorder characterized by the degeneration of long corticospinal neurons, leading to spasticity and weakness in the lower extremities. Atlastin interacts with Spastin, a microtubule-severing AAA ATPase, which is essential for membrane dynamics and cellular transport. This interaction is believed to be a key factor in the biochemical pathways that contribute to the development of HSP. Notably, mutations in the Atlastin gene (SPG3A) are responsible for approximately 10% of all autosomal dominant cases of HSP, highlighting the critical role of Atlastin in neuronal health and disease. Anti-Atlastin antibody (E-9) is an invaluable tool for researchers studying the molecular mechanisms underlying neurodegenerative disorders and the cellular functions of GTPases.
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Atlastin Antibody (E-9) References:
- Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. | Rismanchi, N., et al. 2008. Hum Mol Genet. 17: 1591-604. PMID: 18270207
- Drosophila Atlastin in motor neurons is required for locomotion and presynaptic function. | De Gregorio, C., et al. 2017. J Cell Sci. 130: 3507-3516. PMID: 28860117
- Nucleotide-Dependent Dimerization and Conformational Switching of Atlastin. | O'Donnell, JP., et al. 2020. Methods Mol Biol. 2159: 93-113. PMID: 32529366
- Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate autophagy. | Liu, N., et al. 2021. J Cell Biol. 220: PMID: 33988678
- Endoplasmic Reticulum-Shaping Atlastin Proteins Facilitate KSHV Replication. | Long, WY., et al. 2021. Front Cell Infect Microbiol. 11: 790243. PMID: 35096644
- The Involvement of Atlastin in Dengue Virus and Wolbachia Infection in Aedes aegypti and Its Regulation by aae-miR-989. | Hussain, M., et al. 2022. Microbiol Spectr. 10: e0225822. PMID: 36165808
- Human atlastin-3 is a constitutive ER membrane fusion catalyst. | Bryce, S., et al. 2023. J Cell Biol. 222: PMID: 37102997
- High Atlastin 2-2 (ATL2-2) Expression Associates with Worse Prognosis in Estrogen-Receptor-Positive Breast Cancer. | Reynisdottir, I., et al. 2023. Genes (Basel). 14: PMID: 37628611
- Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling. | Bertin, F., et al. 2023. Biol Res. 56: 49. PMID: 37710314
- Dissecting the mechanism of atlastin-mediated homotypic membrane fusion at the single-molecule level. | Shi, L., et al. 2024. Nat Commun. 15: 2488. PMID: 38509071
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Atlastin Antibody (E-9) | sc-376619 | 200 µg/ml | $322.00 | |||
Atlastin Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-540614 | 200 µg Ab; 10 µg BP | $361.00 | |||
Atlastin Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-542246 | 200 µg Ab; 20 µg BP | $361.00 | |||
Atlastin (E-9) Neutralizing Peptide | sc-376619 P | 100 µg/0.5 ml | $69.00 |