Atipamezole hydrochloride CAS: 104075-48-1
MF: C14H16N2.HCl
MW: 248.75
A selective α2-adrenergic receptor antagonist.

Atipamezole hydrochloride (CAS 104075-48-1)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 146ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Atipamezole hydrochloride is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
Noms alternatifs: 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
Application: Atipamezole hydrochloride is a selective α2-adrenergic receptor antagonist
Numéro CAS: 104075-48-1
Pureté: ≥99%
Masse Moléculaire: 248.75
Formule Moléculaire: C14H16N2.HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Atipamezole hydrochloride is a selective α2-adrenergic receptor antagonist in centrally and peripherally located neurons. Studies indicate that Atipamezole hydrochloride competitively antagonizes Clonidine hydrochloride (sc-203002) and medetomidine hydrochloride (sc-204073) at presynaptic α2-adrenoceptors. In addition, Atipamezole hydrochloride can partially effect the vasoconstrictor effects of activated by α1 receptors. Alternate studies show that α2-adrenergic receptor antagonists such as Atipamezole hydrochloride can inhibit the reduction of both spontaneous and electrically-evoked phasic contractions in samples of equine jejunum from horses via interfering with the ability of agonists to bind to the receptor. Furthermore, studies show that Atipamezole hydrochloride stimulates the release of aldosterone and inhibits the mitochondrial CYP (cytochrome P450). Atipamezole hydrochloride is an inhibitor of α2A-AR, α2B-AR and α2C-AR.


Références

1. Virtanen, R., et al. 1989. Arch Int Pharmacodyn Ther. 297: 190-204. PMID: 2567152
2. Jager, L.P., et al. 1998. Eur. J. Pharmacol. 346: 71-76. PMID: 9617754
3. Zullian, C., et al. 2010. Vet. J. [Epub ahead of print]. PMID: 20093057

État Physique :
Solid
Solubilité :
Soluble in DMSO (100 mM), and water (100 mM).
STOCKAGE :
Desiccate at room temperature
Point de fusion :
211.1-215° C
Ki Data :
α2A receptor: Ki= 1.1 nM; α2B receptor: Ki= 1.0 nM; α2C receptor: Ki= 0.89 nM; α1A receptor: Ki= 1.3 µM; α1B receptor: Ki= 6.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NI6139000
PubChem CID :
13649426
Index Merck :
14: 861
Numéro MDL :
MFCD06407819
SMILES :
CCC1(CC2=CC=CC=C2C1)C3=CN=CN3.Cl

Télécharger la Fiche de Sécurité/ SDS (MSDS)

CERTIFICAT D'ANALYSE

Pour une bonne lecture, Adobe Acrobat Reader est requis,
imprimer et commenter les documents PDF

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 115ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. est leader mondial dans le développement de produits pour la recherche biomédicale. Contactez-nous au 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. Tous Droits Réservés. "Santa Cruz Biotechnology", et le logo Santa Cruz Biotechnology, Inc., "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", le logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", et "EZ Touch" sont des marques déposées de Santa Cruz Biotechnology, Inc.
Toutes les marques sont la propriété de leurs propriétaires respectifs.