Andrographolide (CAS 5508-58-7)

Andrographolide is a bicyclic diterpenoid lactone displaying antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties. This chemical is an irreversible antagonist of NF-κB and prevents in vitro T cell activation. Andrographolide displays no effect on IκBa degradation but downregulates iNOS and Mac-1 expressions and ROS production. It has been shown to prevent endotoxin shock in mouse models and is reported to activate PI 3K/Akt pathways. Andrographolide is also an inhibitor of ERK.

Références

1. Yu, Bu-Chin., et al., 2003. Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta medica. 69(12): 1075-9. PMID: 14750020
2. Chen, Jiun-Han., et al., 2004. Andrographolide suppresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase/Akt pathway. Biochemical pharmacology. 67(7): 1337-45. PMID: 15013849
3. Xia, Yi-Feng., et al., 2004. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. Journal of immunology (Baltimore, Md. : 1950). 173(6): 4207-17. PMID: 15356172