ACCÈS RAPIDE AUX LIENS
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 8, also known as AKAP 95, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 8 is recruited to the chromosomes and plays an essential role in mitotic progression. AKAP 8L (AKAP 8-like), also known as HA95 (homologous to AKAP 95 protein), HAP95 (Helicase A-binding protein 95), NAKAP or NAKAP95 (neighbor of AKAP 95), is also a nuclear matrix protein and shares 61% homology and 30% identity with AKAP 8. In addition, AKAP 8L forms a complex with AKAP 8 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps AKAP 8L (B-6) | sc-376338 | 200 µg/ml | $316.00 | |||
AKAP 8L (B-6): m-IgGλ BP-HRP Kit | sc-522921 | 200 µg Ab, 40 µg BP | $354.00 | |||
AKAP 8L (B-6) peptide neutralisant | sc-376338 P | 100 µg/0.5 ml | $68.00 |