ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The dynamics of a cell-cell interface such as tight junctions or adherens junctions are important in many developmental, physiological, and pathological processes. AF-6 (MLLT4: myeloid/lymphoid or mixed-lineage leukemia trans-located to 4) is a 1,612 amino acid protein that contains two N-terminal Ras binding domains (RBD) and a GLGF motif, and is implicated in Ras-mediated signaling events occurring at peripheral cell-cell junctions. AF-6 interacts with F-actin and Profilin in cell-cell junctions, and may modulate Actin modeling near adhesion complexes. Furthermore, AF-6 coordinates junction adhesion molecule (JAM) recruitment to intercellular junctions through a PDZ domain. Developing mice deficient in AF-6 activity display a loss of neuroepithelial polarity, suggesting that AF-6 activity is an important regulator of cell-cell junctions that influence apical/basolateral asymmetry.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps AF-6 (C-3) | sc-74432 | 200 µg/ml | $316.00 | |||
AF-6 (C-3): m-IgG2a BP-HRP Kit | sc-546011 | 200 µg Ab; 10 µg BP | $354.00 |