The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. ADH8, also known as ADHFE1 (alcohol dehydrogenase, iron containing, 1) or HOT, is a 467 amino acid protein that belongs to the iron-containing alcohol dehydrogenase family and localizes to the mitochondrion. Expressed specifically in adult liver, ADH8 functions to catalyze the cofactor-independent oxidation of gamma-hydroxybutyrate to succinic semialdehyde, a reaction that is coupled to the reduction of 2-ketoglutarate to D-2-hydroxyglutarate and occurs at an optimal pH of 7.5. Succinic semialdehyde can then be converted to succinic acid which is used for energy production in the Krebs cycle. Four isoforms of ADH8 exist due to alternative splicing events.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ADH8 (B-10) | sc-390552 | 200 µg/ml | $316.00 | |||
ADH8 (B-10): m-IgG Fc BP-HRP Kit | sc-540816 | 200 µg Ab; 10 µg BP | $354.00 | |||
ADH8 (B-10): m-IgG2a BP-HRP Kit | sc-546962 | 200 µg Ab; 10 µg BP | $354.00 |