3-Keto Valproic Acid Sodium Salt 3-Keto Valproic Acid Sodium Salt is a useful main metabolite of Valproic Acid.

3-Keto Valproic Acid Sodium Salt (CAS 1184991-15-8)

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Noms alternatifs: 3-keto-VPA; 3-oxo-2-propyl-pentanoic Acid Sodium Salt; 2-Propyl-3-oxopentanoic Acid Sodium Salt;
Application: 3-Keto Valproic Acid Sodium Salt is a useful main metabolite of Valproic Acid
Numéro CAS: 1184991-15-8
Pureté: ≥95%
Masse Moléculaire: 180.18
Formule Moléculaire: C8H13NaO3
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
* Consulter le Certificat d'Analyses pour les données spécifiques à un lot (incluant la teneur en eau).

3-Keto Valproic Acid Sodium Salt is the sodium salt of the main metabolite of Valproic Acid. 3-Keto Valproic Acid is produced from Valproic Acid metabolism by β-oxidation and may be useful for monitoring the metabolism of Valproic Acid in vitro . The parent compound, Valproic Acid, is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Metabolites of Valproic Acid are also available as:
Valproic Acid (sc-213144)
Valproic Acid, Sodium Salt (sc-202378)
3-Hydroxy Valproic Acid (sc-209599)
4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870)
rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266)
Valproic Acid β-D-Glucuronide Allyl Ester (sc-220360)
Valproic Acid β-D-Glucuronide (sc-213145)

Labelled forms of Valproic Acid are available as:
Valproic Acid-d6 (sc-213146)
Valproic Acid-d6 β-D-Glucuronide (sc-220361)
rac 5-Hydroxy Valproic Acid-d7 Sodium Salt (sc-219789)


Références

1. Böhles, H., et al. 1982. Eur. J. Pediatr. 139: 185-186. PMID: 6819143

2. Burchell, B., et al. 1989. Dev Pharmacol Ther. 13: 70-77. PMID: 2515047

3. Bjorge, S.M. and Baillie, T.A. 1991. Drug Metab. Dispos. 19: 823-829. PMID: 1680661

4. Rettie, A.E., et al. 1995. Biochemistry. 34: 7889-7895. PMID: 7794900

5. Bello-Ramírez, A.M., et al. 2002. Epilepsia. 43: 475-481. PMID: 12027907

État Physique :
Solid
STOCKAGE :
Store at -20° C
Point de fusion :
>250° C (dec.)
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
PubChem CID :
45039635
SMILES :
CCCC(C(=O)CC)C(=O)[O-].[Na+]

Télécharger la Fiche de Sécurité/ SDS (MSDS)

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