Inhibiteurs PIAS 1
PIAS1 inhibitors represent a class of chemical compounds that specifically target and inhibit the activity of PIAS1 (Protein Inhibitor of Activated STAT1), a member of the PIAS (Protein Inhibitor of Activated STAT) family. PIAS1 plays a critical role in the regulation of signal transducer and activator of transcription (STAT) proteins, which are vital for transmitting signals from various cytokines and growth factors within cells. By binding to STAT proteins, PIAS1 inhibits their transcriptional activity, thereby modulating the cellular responses to various stimuli. The disruption of this interaction by PIAS1 inhibitors can lead to enhanced STAT signaling, influencing numerous biological processes such as immune responses, cell growth, and differentiation.
The exploration of PIAS1 inhibitors is essential for understanding the intricate regulatory mechanisms that govern cell signaling pathways. These inhibitors serve as valuable tools for dissecting the specific functions of PIAS1 in various cellular contexts, enabling researchers to elucidate its role in mediating the effects of different cytokines and growth factors. By studying the impact of PIAS1 inhibition on STAT activity, researchers can gain insights into how this regulation affects downstream gene expression and cellular behavior. Furthermore, understanding the interactions between PIAS1 and STAT proteins can reveal important information about the balance of signaling pathways in cellular homeostasis. Thus, PIAS1 inhibitors contribute significantly to the broader field of signal transduction research, enhancing our comprehension of cellular responses to environmental cues and the regulatory networks that govern them.
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| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibiteur de PI3K qui se lie directement à PI3K, stoppant la phosphorylation d'Akt, un effecteur en aval qui pourrait activer PIA indirectement. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibiteur de la voie ERK qui se lie à MEK, inhibant l'activation d'ERK, qui peut autrement phosphoryler PIA ou ses régulateurs en amont. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Autre inhibiteur de la PI3K, il cible également l'Akt, un effecteur en aval de la PI3K, qui inhiberait indirectement l'activation de la PIA. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibiteur de la MAPK P38 qui arrête la signalisation en aval médiée par la p38. Si le PIA est un substrat de la p38, cela conduira à son inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibiteur de JNK qui empêche l'activation de c-Jun. Cela pourrait bloquer la transcription de PIA dépendante de c-Jun. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibiteur de mTOR qui inhibe l'activation de la kinase p70S6 et peut entraîner une diminution de la traduction de la protéine PIA. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Inhibiteur de l'EGFR qui bloque l'activation des voies Akt et ERK en aval, conduisant à la modulation de la PIA. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Inhibiteur de kinases à large spectre affectant de multiples voies, y compris la PKC qui, si elle régule l'AIP, inhibe son activité. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Inhibiteur de Bcr-Abl affectant l'activité tyrosine kinase. Si le PIA est phosphorylé par Bcr-Abl, l'imatinib inhiberait cette interaction. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Inhibiteur de kinases de la famille Src qui entrave les événements de phosphorylation médiés par Src et modulerait l'IAE s'il s'agit d'un substrat de Src. | ||||||