Date published: 2026-6-3

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CaMKIV Substrates

Santa Cruz Biotechnology now offers a broad range of CaMKIV Substrates for use in various applications. CaMKIV substrates are essential tools for studying the functions and regulatory mechanisms of calcium/calmodulin-dependent protein kinase IV (CaMKIV), a serine/threonine kinase involved in a variety of critical cellular processes such as gene expression, cell differentiation, and synaptic plasticity. These substrates are specifically phosphorylated by CaMKIV, allowing researchers to track and measure kinase activity, which is vital for understanding how CaMKIV influences cellular signaling pathways. By using CaMKIV substrates, scientists can explore the kinase's role in regulating transcription factors, such as CREB, and its impact on long-term memory formation and other neuronal functions. These substrates are widely employed in biochemical assays designed to study the specificity and efficiency of CaMKIV in phosphorylating its targets, helping to map out the broader signaling networks in which CaMKIV plays a role. Additionally, CaMKIV substrates are crucial for high-throughput screening applications aimed at identifying novel regulators of CaMKIV activity, thereby expanding the understanding of how this kinase integrates calcium signaling into cellular responses. The ability to precisely monitor CaMKIV activity using these substrates provides invaluable insights into how calcium-dependent kinases orchestrate complex biological processes, from development to adaptive cellular responses. View detailed information on our available CaMKIV Substrates by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

CaM Kinase IV substrate

sc-3028
0.5 mg/0.1 ml
$96.00
(0)

CaM Kinase IV substrate is integral to calcium signaling, specifically influencing the activation of CaMKIV. Phosphorylation of this substrate alters its conformation, enhancing its interaction with transcription factors. This modification facilitates the translocation of CaMKIV to the nucleus, where it regulates gene expression. The kinetics of this reaction are crucial, as they determine the timing and intensity of cellular responses to calcium fluctuations, impacting various physiological processes.