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Este anticorpo policlonal foi descontinuado. Consulta o nosso anticorpo monoclonal XRCC1 (AP-39) recomendado (dados de amostra apresentados).
XRCC1 Anticorpo (H-300): sc-11429
- XRCC1 Anticorpo H-300 é um anticorpo policlonal produzido em coelho IgG fornecido em200 µg/ml
- epítopo correspondente aos aminoácidos 1-300 mapeados no N-terminus de XRCC1 de human origem
- Anticorpo policlonal descontinuado
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad5. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
Informacoes sobre ordens
XRCC1 (AP-39): sc-517377 [ anticorpo monoclonal substituto recomendado para XRCC1 (H-300) ]
| Nome do Produto | Numero de Catalogo | UNID | Preco | Qde | FAVORITOS | |
XRCC1 Anticorpo (AP-39) | sc-517377 | 100 µg/ml | $322.00 |