Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC>sub>50 = 0.9 μM).
Estado de Materia
Soluble in 1:10 DMSO:PBS(pH7.2) (~0.1 mg/mL), ethanol (~0.2 mg/mL), DMF (~5 mg/mL), and DMSO (~5 mg/mL).
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