TRPC5 Antibody (1C8): sc-293259
- TRPC5 Antibody (1C8) is a mouse monoclonal IgG2a κ TRPC5 antibody, cited in 3 publications, provided at 100 µg/ml
- raised against a partial recombinant protein corresponding to amino acids 534-603 of TRPC5 of human origin
- recommended for detection of TRPC5 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRPC5 Antibody (1C8). This work is in progress.
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TRPC5 Antibody (1C8) is a mouse monoclonal IgG2a kappa light chain antibody that detects TRPC5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TRPC5 antibody (1C8) is available as the non-conjugated format. TRPC5, a member of the transient receptor potential (TRP) ion channel superfamily, plays a crucial role in mediating store-operated calcium entry, which is essential for various cellular processes, including muscle contraction, neurotransmitter release, and gene expression. TRPC5 is primarily located in the plasma membrane of excitable cells, such as neurons and muscle cells, where TRPC5 facilitates the influx of calcium ions in response to various stimuli. TRPC5′s ability to regulate calcium levels is vital for maintaining cellular homeostasis and responding to environmental changes, making TRPC5 a key player in physiological functions and potential pathophysiological conditions. The gene encoding human TRPC5 is located on chromosome Xp23, an area associated with several genetic disorders, highlighting TRPC5′s importance in both health and disease.
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TRPC5 Antibody (1C8) References:
- Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel. | Sossey-Alaoui, K., et al. 1999. Genomics. 60: 330-40. PMID: 10493832
- From worm to man: three subfamilies of TRP channels. | Harteneck, C., et al. 2000. Trends Neurosci. 23: 159-66. PMID: 10717675
- Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. | Hofmann, T., et al. 2000. J Mol Med (Berl). 78: 14-25. PMID: 10759026
- TRPC1 and TRPC5 form a novel cation channel in mammalian brain. | Strübing, C., et al. 2001. Neuron. 29: 645-55. PMID: 11301024
- TRPC5 in cardiovascular diseases. | Du, SL., et al. 2021. Rev Cardiovasc Med. 22: 127-135. PMID: 33792254
- TRPC5 as a possible therapeutic target for vascular dysfunction associated with obesity. | Wakui, H., et al. 2022. Hypertens Res. 45: 2018-2020. PMID: 36123400
- Molecular architecture of the Gαi-bound TRPC5 ion channel. | Won, J., et al. 2023. Nat Commun. 14: 2550. PMID: 37137991
- The TRPC5 receptor as pharmacological target for pain and metabolic disease. | Khare, P., et al. 2024. Pharmacol Ther. 263: 108727. PMID: 39384022
- TRPC1, a human homolog of a Drosophila store-operated channel. | Wes, PD., et al. 1995. Proc Natl Acad Sci U S A. 92: 9652-6. PMID: 7568191
- Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. | Zhu, X., et al. 1995. FEBS Lett. 373: 193-8. PMID: 7589464
- Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. | Zitt, C., et al. 1996. Neuron. 16: 1189-96. PMID: 8663995
- A novel capacitative calcium entry channel expressed in excitable cells. | Philipp, S., et al. 1998. EMBO J. 17: 4274-82. PMID: 9687496
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRPC5 Antibody (1C8) | sc-293259 | 100 µg/ml | $322.00 |