Date published: 2026-10-17

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TIMP-1 抗体 (G-6): sc-365905

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说明书
  • TIMP-1 抗体 G-6 是小鼠单克隆 IgG1 κ,TIMP-1抗体, 在31篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的TIMP-1的C-terminus附近的氨基酸172-207之间
  • TIMP-1 抗体 (G-6) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 TIMP-1
  • 抗TIMP-1抗体(G-6)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP是TIMP-1 Antibody (G-6) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与TIMP-1 Antibody (G-6) 搭配使用(请参阅下面的订购信息)。
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TIMP-1抗体(G-6)是一种IgG1 κ小鼠单克隆TIMP-1抗体(也称为TIMP1抗体),可通过WB、IP、IF和ELISA检测人类来源的TIMP-1蛋白。TIMP-1抗体(G-6)既可作为非偶联抗TIMP-1抗体形式,也可作为多种偶联形式的抗TIMP-1抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。TIMP-1、TIMP-2、TIMP-3和TIMP-4(金属蛋白酶组织抑制剂1、2、3和4)与金属蛋白酶(如胶原酶、明胶酶和基质溶解素)的复合物,导致金属蛋白酶的不可逆失活。已发现TIMP-1与EPA(红细胞增强活性)相同。已显示甲状旁腺激素是成骨细胞中TIMP-2的调节剂。TIMP-3可能参与调节滋养层细胞对子宫的侵袭以及在上皮折叠和上皮管形成、分支和扩展过程中细胞外基质的重塑。TIMP-4在心脏中表达最高,在肝脏、大脑、肺、胸腺和脾脏中表达水平较低。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TIMP-1 抗体 (G-6) 参考文献:

  1. TIMP-1 参与 PECAM-1 介导的肿瘤扩散。  |  Abraham, V., et al. 2018. Int J Oncol. 53: 488-502. PMID: 29845213
  2. TIMP-1通过受体介导的信号传导促进少突胶质细胞分化。  |  Nicaise, AM., et al. 2019. Mol Neurobiol. 56: 3380-3392. PMID: 30121936
  3. TIMP-1通过诱导IL-6对NSCLC产生化疗耐药性  |  Xiao, W., et al. 2019. Cancers (Basel). 11: PMID: 31443242
  4. CAF驱动的TIMP-1/CD63/ITGB1/STAT3反馈回路促进乳腺癌细胞的迁移和生长。  |  Dittmer, A. and Dittmer, J. 2022. Cancers (Basel). 14: PMID: 36291767
  5. 血浆TIMP-1作为急性肺损伤的性别特异性生物标志物  |  Almuntashiri, S., et al. 2022. Biol Sex Differ. 13: 70. PMID: 36482481
  6. COVID-19发病时的循环组织金属蛋白酶抑制剂1(TIMP-1)可预测严重程度。  |  Brusa, S., et al. 2022. Front Med (Lausanne). 9: 1034288. PMID: 36523781
  7. TIMP-1是淀粉样前体蛋白的一种新型配体,可引发人类单核细胞的促炎表型。  |  Eckfeld, C., et al. 2023. J Cell Biol. 222: PMID: 36629908
  8. MMP-9、TIMP-1和MMP-9/TIMP-1比值对诊断和评估慢性阻塞性肺病严重程度的作用  |  Dimic-Janjic, S., et al. 2023. Eur J Med Res. 28: 127. PMID: 36935521
  9. 星形胶质细胞 TIMP-1 调节少突胶质细胞分化和 FTY720 反应抑制剂 Anastellin 的产生。  |  Sutter, PA., et al. 2024. Proc Natl Acad Sci U S A. 121: e2306816121. PMID: 38266047
  10. TIMP-1是髓样树突状细胞中MHC-I表达的激活因子,对肿瘤免疫原性有重要意义。  |  Langguth, M., et al. 2024. Genes Immun. 25: 188-200. PMID: 38777826

订购信息

产品名称产品编号规格价格数量收藏夹

TIMP-1 抗体 (G-6)

sc-365905
200 µg/ml
$322.00

TIMP-1 (G-6): m-IgG Fc BP-HRP 套装

sc-525907
200 µg Ab; 10 µg BP
$361.00

TIMP-1 抗体 (G-6) AC

sc-365905 AC
500 µg/ml, 25% agarose
$424.00

TIMP-1 抗体 (G-6) HRP

sc-365905 HRP
200 µg/ml
$322.00

TIMP-1 抗体 (G-6) FITC

sc-365905 FITC
200 µg/ml
$336.00

TIMP-1 抗体 (G-6) PE

sc-365905 PE
200 µg/ml
$349.00

TIMP-1 抗体 (G-6) Alexa Fluor® 488

sc-365905 AF488
200 µg/ml
$364.00

TIMP-1 抗体 (G-6) Alexa Fluor® 546

sc-365905 AF546
200 µg/ml
$364.00

TIMP-1 抗体 (G-6) Alexa Fluor® 594

sc-365905 AF594
200 µg/ml
$364.00

TIMP-1 抗体 (G-6) Alexa Fluor® 647

sc-365905 AF647
200 µg/ml
$364.00

TIMP-1 抗体 (G-6) Alexa Fluor® 680

sc-365905 AF680
200 µg/ml
$364.00

TIMP-1 抗体 (G-6) Alexa Fluor® 790

sc-365905 AF790
200 µg/ml
$364.00

TIMP-1 (G-6) 中和勝肽

sc-365905 P
100 µg/0.5 ml
$69.00

Is this antibody capable of mouse TIMP-1 detection?

Asked by: mkuw
Thank you for your question. This antibody is recommended for human use, it has not been tested for mouse samples. We do not warranty it for use on mouse samples, although it may work. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com, if you would like to try a sample of sc-365905.
Answered by: Tech Service
Date published: 2017-08-28

What application is the blocking peptide sc-365905 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by Hlyang from Great product!!It's a great product for me to analyze Western blotting.
Date published: 2018-04-22
Rated 5 out of 5 by JoeB from works as advertisedWorks well for western blotting of tissue homogenates
Date published: 2018-03-29
Rated 5 out of 5 by AndreS from great western blot resultsOur lab had great WB results with the TIMP-1 (G-6) antibody for mouse brain lysates. 1:250
Date published: 2017-09-26
Rated 5 out of 5 by 古月天古月天 from Produced nice Western blot data of TIMP-1Produced nice Western blot data of TIMP-expression in rat uterus tissue.
Date published: 2017-08-11
Rated 5 out of 5 by Koti from TIMP-1 works goodI bought this antibody and used for western blot. This antibody works good.
Date published: 2017-05-30
Rated 5 out of 5 by bexa1 from strong bandIt worked for my western blot, but has a little background,strong band.
Date published: 2017-04-23
Rated 5 out of 5 by Pangpang from strong bandsOur lab recommended for detection of human brain for WB, strong bands.
Date published: 2017-02-26
Rated 5 out of 5 by Stephen Curry from TIMP-1 got the WB doneTIMP-1 got my WB done with a strong signal in LX-2, human hepatic stellate cell.
Date published: 2017-02-15
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TIMP-1 抗体 (G-6) is rated 4.9 out of 5 by 15.
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