TCR V β 16 Antibody (3H3009): sc-73127

TCR V β 16 Antibody (3H3009) is a mouse monoclonal IgG1 kappa light chain antibody that detects TCR V beta 16 protein of mouse and rat origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-TCR V beta 16 antibody (3H3009) is available as non-conjugated format. T cell antigen receptor (TCR) plays a crucial role in immune response by recognizing foreign antigens and initiating intracellular signaling pathways that lead to T cell activation. This process enables T cells to respond effectively to pathogens. TCR is a heterodimer composed of either alpha and beta or gamma and delta chains, with most circulating T cells (approximately 95%) expressing alpha/beta heterodimer. TCR repertoire diversity is essential for recognizing various antigens, achieved through somatic recombination of variable (V), diversity (D), and joining (J) gene segments during T cell development. Genes encoding TCR beta and gamma chains are located in distinct loci, while alpha and delta chain genes are found within a single locus. Genetic mutations in T cell receptor beta locus have been linked to T cell lymphomas, highlighting TCR′s importance in maintaining immune system integrity.

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TCR V β 16 Antibody (3H3009) References:

1. Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily.  |  Behlke, MA., et al. 1987. J Exp Med. 165: 257-62. PMID: 2432150
2. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.  |  Staerz, UD., et al. 1985. J Immunol. 134: 3994-4000. PMID: 2580901
3. Methods for the selection and growth of antigen-specific cytolytic T lines and clones bearing a defined T cell receptor beta chain marker.  |  Ito, M., et al. 1987. J Immunol Methods. 103: 229-37. PMID: 2959725
4. T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease.  |  Gold, R., et al. 1995. Proc Natl Acad Sci U S A. 92: 5850-4. PMID: 7597040
5. Discrepancy in T cell clonal expansions in synovial fluid and peripheral blood from rheumatoid arthritis patients.  |  Choi, IH., et al. 1995. Yonsei Med J. 36: 68-76. PMID: 7740838
6. A mouse monoclonal antibody specific for the V beta 5.3 chain of the human TcR recognizes a subgroup of the mouse TcR V beta 8.2 chains.  |  Bleux, C., et al. 1995. J Leukoc Biol. 57: 491. PMID: 7884322
7. Selective activation and accumulation of oligoclonal V beta-specific T cells in active pulmonary sarcoidosis.  |  Forman, JD., et al. 1994. J Clin Invest. 94: 1533-42. PMID: 7929830
8. Dominant V beta 8 gene usage in response to TNP: failure to use other V beta chains following removal of V beta 8+ T cells by monoclonal antibody in vivo.  |  Dieli, F., et al. 1994. Immunology. 82: 99-105. PMID: 8045598
9. T cell vaccination against autoimmune diabetes in nonobese diabetic mice.  |  Formby, B. and Shao, T. 1993. Ann Clin Lab Sci. 23: 137-47. PMID: 8096128
10. T cell receptor V beta gene bias in rheumatoid arthritis.  |  Jenkins, RN., et al. 1993. J Clin Invest. 92: 2688-701. PMID: 8254025
11. Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan.  |  Mokyr, MB., et al. 1993. J Immunol. 151: 4838-46. PMID: 8409442
12. Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice.  |  Mendel Kerlero de Rosbo, N. and Ben-Nun, A. 1996. Eur J Immunol. 26: 2470-9. PMID: 8898962

The preferred TCR β antibody is TCR β Antibody (G-11): sc-5277.