Taxol Antibody (29B7B3C): sc-69900
- Taxol Antibody (29B7B3C) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against taxol-BSA conjugate
- recommended for detection of Taxol and taxotere by ELISA; may cross-react with cephalomannine and 7-epitaxol; useful in Tubulin disassembly assays and cytotoxicity studies using Taxol derivatives
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Taxol Antibody (29B7B3C). This work is in progress.
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Taxol Antibody (29B7B3C) is a mouse monoclonal IgM antibody that detects Taxol of non-species reactive (NSR) by enzyme-linked immunosorbent assay (ELISA). Taxol, also known as Paclitaxel, is a potent mitotic inhibitor derived from the bark of the Pacific yew tree (Taxus brevifolia) and is extensively utilized in cancer chemotherapy for treating various malignancies, including ovarian, lung, breast, prostate, and head and neck cancers. Taxol plays a crucial role in disrupting normal microtubule dynamics during cell division, as Taxol binds to β Tubulin, promoting the polymerization and stabilization of microtubules. This action leads to G2/M phase arrest, ultimately triggering apoptosis in cancer cells. Understanding the structure of Taxol is vital, as Taxol′s unique ability to stabilize microtubules makes Taxol an effective therapeutic agent, yet also contributes to the development of drug resistance and significant side effects, such as peripheral neurotoxicity. This side effect arises when Taxol affects large myelinated nerve fibers, resulting in mixed motor and sensory dysfunction that can lead to debilitating symptoms. Anti-Taxol antibody (29B7B3C) is an essential tool for researchers studying the mechanisms of action and resistance associated with this important chemotherapeutic agent.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Taxol Antibody (29B7B3C) | sc-69900 | 200 µg/ml | $322.00 |