Sur-8 Antibody (E-4): sc-514886

Sur-8 Antibody (E-4) is a mouse monoclonal IgG2a antibody that detects Sur-8 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sur-8, also known as SHOC2 (soc-2 suppressor of clear homolog (C. elegans)), is a 582 amino acid protein that plays a crucial role in the regulation of Ras-MAPK signaling pathways, which are essential for cell growth and differentiation. Sur-8 (E-4) antibody targets a protein primarily located in the cytoplasm but translocates to the nucleus upon growth factor stimulation, highlighting its dynamic role in cellular signaling. Sur-8 exists in two alternatively spliced isoforms and features 20 leucine-rich repeats (LRR), which are important for protein-protein interactions and stability. Notably, aberrant N-myristoylation of SHOC2 has been linked to Noonan-like syndrome with loose anagen hair, a genetic disorder that results in distinctive physical features and hair abnormalities. The gene encoding Sur-8 is located on human chromosome 10q25.2 and murine chromosome 19 D2, making Sur-8 (E-4) monoclonal antibody a significant tool for research into developmental disorders and signaling pathways. anti-Sur-8 antibody (E-4) is valuable for investigating the complexities of Ras-MAPK signaling and its implications in various biological processes and diseases.

The preferred Sur-8 antibody is Sur-8 Antibody (D-8): sc-514779.