Snurportin-1 Antibody (F-2): sc-166006

Snurportin-1 Antibody (F-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Snurportin-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Snurportin-1 antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Snurportin-1, also known as SNUPN, KPNBL, or RNUT1 (RNA U transporter 1), is a crucial nuclear import adaptor protein that plays a significant role in transporting U small nuclear ribonucleoproteins (U snRNPs) into the nucleus, essential for spliceosome maturation. Snurportin-1 is primarily located in the cytoplasm and nucleus, containing an N-terminal importin β-binding (IBB) domain and a trimethylguanosine (m3G)-cap binding domain. This unique structure allows Snurportin-1 to specifically bind to the terminal 2,2,7-m3G-cap at the 5′ end of U snRNPs, facilitating nuclear import through interaction with Importin β. Formation of the complex between Snurportin-1, U snRNPs, and Importin β is vital for effective nuclear import. After import, Snurportin-1 may localize to Cajal bodies, depending on the specific U snRNP involved, such as U1 or U2. In the nucleus, Snurportin-1 interacts with CRM1, responsible for recycling Snurportin-1 back to the cytoplasm, enabling further rounds of U snRNP import. This dynamic process underscores Snurportin-1′s importance in RNA processing and gene expression regulation.

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Snurportin-1 Antibody (F-2) References:

1. CRM1-mediated recycling of snurportin 1 to the cytoplasm.  |  Paraskeva, E., et al. 1999. J Cell Biol. 145: 255-64. PMID: 10209022
2. Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron.  |  Mouaikel, J., et al. 2003. EMBO Rep. 4: 616-22. PMID: 12776181
3. Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression.  |  Julien, C., et al. 2003. J Biol Chem. 278: 42615-24. PMID: 12915405
4. Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1.  |  Strasser, A., et al. 2004. Acta Crystallogr D Biol Crystallogr. 60: 1628-31. PMID: 15333938
5. Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex.  |  Mans, BJ., et al. 2004. Cell Cycle. 3: 1612-37. PMID: 15611647
6. Crm1 is a mitotic effector of Ran-GTP in somatic cells.  |  Arnaoutov, A., et al. 2005. Nat Cell Biol. 7: 626-32. PMID: 15908946
7. Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1.  |  Strasser, A., et al. 2005. EMBO J. 24: 2235-43. PMID: 15920472
8. Cross-talk between snurportin1 subdomains.  |  Ospina, JK., et al. 2005. Mol Biol Cell. 16: 4660-71. PMID: 16030253
9. Trimethylguanosine nucleoside inhibits cross-linking between Snurportin 1 and m3G-CAPPED U1 snRNA.  |  Bahia, D., et al. 2006. Nucleosides Nucleotides Nucleic Acids. 25: 909-23. PMID: 16901822

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Snurportin-1 Antibody (F-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Snurportin-1 Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Snurportin-1 Antibody (F-2) Specifications

Alternate Product Name: Snurportin-1

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 11-43

Epitope Target: Snurportin-1

Epitope Species: human

Product Reactivity/Detection: Snurportin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Snurportin-1 Antibody (F-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin