SN-6 CAS: 415697-08-4
MF: C20H22N2O5S
SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor.

SN-6 (CAS 415697-08-4)

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Nombres Alternativos: 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
Solicitud: SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor
Número de CAS: 415697-08-4
Pureza: ≥98%
Peso Molecular: 402.16
Fórmula Molecular: C20H22N2O5S
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

SN-6 is a selective Na+/Ca2+exchange (NCX) inhibitor, displaying some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. SN-6 has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943. This compound acts as an anti-ischemic, potently protecting against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).


References

1. Inoue, Y., Ito, K., Sakaue, T., Iwamoto, T. and Kita, S. 2004. Characterization of SN-6, a novel exchange inhibitor and its renal protective effect]. Clin Calcium. 14(8): 84-91. PMID: 15577102

2. Iwamoto, T. 2004. Forefront of Na+/Ca2+ exchanger studies: molecular pharmacology of Na+/Ca2+ exchange inhibitors. J. Pharmacol. Sci. 96(1): 27-32. PMID: 15359084

3. Iwamoto, T., Inoue, Y., Ito, K., Sakaue, T., Kita, S. and Katsuragi, T. 2004. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol. Pharmacol. 66(1): 45-55. PMID: 15213295

4. Iwamoto, T. and Kita, S. 2006. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol. Pharmacol. 70(6): 2075-2083. PMID: 16973719

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (100 mM).
ALMACENAMIENTO :
Desiccate at 4° C
Punto de Fusión :
222.14° C (Predicted)
Punto de ebullición :
~581.2° C at 760 mmHg (Predicted)
Densidad :
~1.3 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.61 (Predicted)
IC50 :
Hypoxia-induced renal tubular cell damage: IC50 = 0.63 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1: IC50 = 2.9 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX3: IC50 = 8.6 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX2: IC50 = 16 µM; mACh receptors : IC50 = 18 µM
Valores de pK :
pKb: 6.63 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
Número MDL :
MFCD06798326
SMILES :
CCOC(=O)C1CSC(N1)CC2=CC=C(C=C2)OCC3=CC=C(C=C3)[N+](=O)[O-]

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Citaciones 1 a 2 de un total de 2

PMID: # 30892074  Amarelle, L. et al. 2019. Am. J. Physiol. Lung Cell Mol. Physiol. 316: L1094-L1106.

PMID: # 26418956  van der Hagen, EA.|van Loon, EP.|Verkaart, S.|Latta, F.|Bindels, RJ.|Hoenderop, JG.| et al. 2015. Nephron. 131: 145-52.

Citaciones 1 a 2 de un total de 2
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