Septin 8 Antibody (D-11): sc-515096
- Septin 8 Antibody (D-11) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 426-483 mapping at the C-terminus of Septin 8 of human origin
- recommended for detection of Septin 8 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Septin 8 Antibody (D-11) for WB applications. This reagent is now offered in a bundle with Septin 8 Antibody (D-11) (see ordering information below).
Septin 8 Antibody (D-11) is a mouse monoclonal IgG2b antibody that detects Septin 8 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Septin 8 is a 508 amino acid protein that plays a crucial role in various cellular processes, including vesicle trafficking, apoptosis, and cytokinesis, making Septin 8 essential for maintaining cellular integrity and function. Septin 8 is predominantly expressed in the brain, cardiovascular regions, prostate, testis, and ovary, highlighting Septin 8′s significance in both neural and reproductive health. Notably, Septin 8 interacts with other septins, such as Septin 5, and cell division cycle related-1 (CDCrel-1), suggesting Septin 8′s involvement in complex protein networks that regulate cell division and signaling pathways. Septin 8′s ability to form oligomeric structures allows Septin 8 to act as a dynamic scaffold, which is vital for the organization of the cytoskeleton and proper functioning of platelets, where Septin 8 surrounds α-granules and contributes to platelet biology. Anti-Septin 8 antibody (D-11) enables researchers to gain valuable insights into Septin 8′s role in various physiological and pathological processes, furthering understanding of Septin 8′s implications in diseases such as neurodegeneration and cancer.
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Septin 8 Antibody (D-11) References:
- Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells. | Sui, L., et al. 2003. Biochem Biophys Res Commun. 304: 393-8. PMID: 12711328
- Localization of septin 8 in murine retina, and spatiotemporal expression of septin 8 in a murine model of photoreceptor cell degeneration. | Hara, A., et al. 2007. Neurosci Lett. 423: 205-10. PMID: 17709200
- Proteomic analysis in NSAIDs-treated primary cardiomyocytes. | Baek, SM., et al. 2010. J Proteomics. 73: 721-32. PMID: 19850159
- Cloning, overexpression, purification and preliminary characterization of human septin 8. | Souza, TA. and Barbosa, JA. 2010. Protein J. 29: 328-35. PMID: 20544379
- Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization. | Sevinc, A. and Fung, LW. 2011. Cell Mol Biol Lett. 16: 595-609. PMID: 21866423
- Septin 8 is an interaction partner and in vitro substrate of MK5. | Shiryaev, A., et al. 2012. World J Biol Chem. 3: 98-109. PMID: 22649572
- Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons. | Yuan, Y., et al. 2018. Genome Biol. 19: 117. PMID: 30111345
- Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model. | Keele, GR., et al. 2021. Sci Rep. 11: 2071. PMID: 33483609
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Septin 8 Antibody (D-11) | sc-515096 | 200 µg/ml | $322.00 | |||
Septin 8 Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-541028 | 200 µg Ab; 10 µg BP | $361.00 |