RPTPα Antibody (C-8): sc-398243
- RPTPα Antibody (C-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 194-225 within an internal region of RPTPα of human origin
- recommended for detection of RPTPα of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RPTPα Antibody (C-8) for WB applications. These reagents are now offered in bundles with RPTPα Antibody (C-8) (see ordering information below).
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RPTPα Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects receptor protein-tyrosine phosphatase α (RPTPα) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RPTPα plays a crucial role in cellular signaling by dephosphorylating and activating Src family tyrosine kinases, which are essential for regulating integrin signaling, cell adhesion, and growth factor responsiveness. RPTPα is located in the cell membrane, where RPTPα contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, allowing RPTPα to form constitutive dimers that enhance functional capacity. The human RPTPα sequence encodes a 793 amino acid protein, and in mouse models, RPTPα is known to be constitutively phosphorylated at Ser 180 and Ser 204, which may influence activity and interactions. Additionally, RPTPα serves as a receptor for the Helicobacter pylori vacuolating cytotoxin, VacA, highlighting RPTPα′s importance in both normal cellular functions and pathogenic processes. Anti-RPTPα antibody (C-8) is an invaluable tool for researchers studying the intricate roles of RPTPα in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RPTPα Antibody (C-8) | sc-398243 | 200 µg/ml | $322.00 | |||
RPTPα Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-538402 | 200 µg Ab; 10 µg BP | $361.00 | |||
RPTPα Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-536011 | 200 µg Ab; 40 µg BP | $361.00 | |||
RPTPα Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-545683 | 200 µg Ab; 20 µg BP | $361.00 | |||
RPTPα (C-8) Neutralizing Peptide | sc-398243 P | 100 µg/0.5 ml | $69.00 |