Reptin 52 Antibody (B-9): sc-365326
- Reptin 52 Antibody (B-9) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 11-37 at the N-terminus of Reptin 52 of human origin
- recommended for detection of Reptin 52 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-365326 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Reptin 52 Antibody (B-9) for WB applications. This reagent is now offered in a bundle with Reptin 52 Antibody (B-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Reptin 52 Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects Reptin 52 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Reptin 52, also known as RUVBL2, is a crucial member of the ATPase/helicase family and plays a significant role in various cellular processes, including transcriptional regulation and chromatin remodeling. Reptin 52 is primarily located in the nucleus, where RUVBL2 is involved in the assembly of transcriptional complexes and the modulation of gene expression. Nuclear localization of Reptin 52 is vital for function, as RUVBL2 interacts with key transcription factors, including Myc and Pontin 52, to facilitate oncogenic signaling pathways. Notably, the interaction between Reptin 52 and Myc is essential for Myc′s oncogenic activity, highlighting RUVBL2′s importance in cancer biology. Additionally, Reptin 52 undergoes post-translational modifications, such as phosphorylation, which can influence activity and interactions, further underscoring RUVBL2′s role in regulating cellular functions. With diverse applications and critical involvement in cellular mechanisms, anti-Reptin 52 antibody (B-9) serves as an invaluable tool for researchers studying gene regulation and cancer progression.
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Reptin 52 Antibody (B-9) References:
- Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complex. | Gorynia, S., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 840-6. PMID: 18765919
- Reptin52 expression during in vitro neural differentiation of human embryonic stem cells. | Barthéléry, M., et al. 2009. Neurosci Lett. 452: 47-51. PMID: 19444951
- RUVBL2, a novel AS160-binding protein, regulates insulin-stimulated GLUT4 translocation. | Xie, X., et al. 2009. Cell Res. 19: 1090-7. PMID: 19532121
- RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer. | Flavin, P., et al. 2011. FEBS Lett. 585: 2537-44. PMID: 21763315
- Clustering of GLUT4, TUG, and RUVBL2 protein levels correlate with myosin heavy chain isoform pattern in skeletal muscles, but AS160 and TBC1D1 levels do not. | Castorena, CM., et al. 2011. J Appl Physiol (1985). 111: 1106-17. PMID: 21799128
- RUVBL2 is a novel repressor of ARF transcription. | Xie, C., et al. 2012. FEBS Lett. 586: 435-41. PMID: 22285491
- RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. | Zaarur, N., et al. 2015. EMBO J. 34: 2363-82. PMID: 26303906
- RuvB-Like Protein 2 (Ruvbl2) Has a Role in Directing the Neuroectodermal Differentiation of Mouse Embryonic Stem Cells. | Hong, S., et al. 2016. Stem Cells Dev. 25: 1376-85. PMID: 27469992
- Identification of RUVBL1 and RUVBL2 as Novel Cellular Interactors of the Ebola Virus Nucleoprotein. | Morwitzer, MJ., et al. 2019. Viruses. 11: PMID: 31018511
- Reptin/RUVBL2 is required for hepatocyte proliferation in vivo, liver regeneration and homeostasis. | Javary, J., et al. 2021. Liver Int. 41: 1423-1429. PMID: 33792165
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Reptin 52 Antibody (B-9) | sc-365326 | 200 µg/ml | $322.00 | |||
Reptin 52 Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-522207 | 200 µg Ab, 40 µg BP | $361.00 | |||
Reptin 52 (B-9) Neutralizing Peptide | sc-365326 P | 100 µg/0.5 ml | $69.00 | |||
Reptin 52 Antibody (B-9) X | sc-365326 X | 200 µg/0.1 ml | $322.00 |