Molecular structure of R-(+)-Baclofen hydrochloride, CAS Number: 63701-55-3
R-(+)-Baclofen hydrochloride (CAS 63701-55-3)
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Alternate Names:
CG15274; R-(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid . HCl; R-(+)-4-Amino-3-(4-chlorophenyl)butanoic acid . HCl
Application:
R-(+)-Baclofen hydrochloride is a seelctive GABAB receptor agonist
CAS Number:
63701-55-3
Purity:
≥98%
Molecular Weight:
250.12
Molecular Formula:
C10H12ClNO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
R-(+)-Baclofen hydrochloride is the hydrochloride salt preparation of the 3-(p-chlorophenyl)-4-aminobutanoic acid R-(+) enantiomer, an derivative of GABA and a selective agonist of the GABAB receptor. The R-(+)-Baclofen isomer is described to be 4.2-9.2-fold as effective as the S-(−) isomer.
R-(+)-Baclofen hydrochloride (CAS 63701-55-3) References
- Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. | Hong, YG. and Henry, JL. 1991. Eur J Pharmacol. 196: 267-75. PMID: 1654254
- Effects of GABAB receptor ligands in animal tests of depression and anxiety. | Frankowska, M., et al. 2007. Pharmacol Rep. 59: 645-55. PMID: 18195453
- Identification of G protein-coupled receptors in the pea aphid, Acyrthosiphon pisum. | Li, C., et al. 2013. Genomics. 102: 345-54. PMID: 23792713
- Identification and comparative analysis of G protein-coupled receptors in Pediculus humanus humanus. | Li, C., et al. 2014. Genomics. 104: 58-67. PMID: 24952173
- Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. | Falch, E., et al. 1986. J Neurochem. 47: 898-903. PMID: 3016189
- 3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity. | Witczuk, B., et al. 1980. Pol J Pharmacol Pharm. 32: 187-96. PMID: 7454623
- Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats. | Thomas, DA., et al. 1996. Brain Res. 718: 129-37. PMID: 8773775
Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R-(+)-Baclofen hydrochloride, 10 mg | sc-203229 | 10 mg | $31.00 | |||
R-(+)-Baclofen hydrochloride, 50 mg | sc-203229A | 50 mg | $119.00 |