PSGL-1 Antibody (HECA-452): sc-53514
- PSGL-1 Antibody (HECA-452) is a rat monoclonal IgM, cited in 1 publications, provided at 200 µg/ml
- raised against skin homing memory cells of human origin
- recommended for detection of PSGL-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM; also recommended for detection of skin-homing memory T cells, binding to the T cell carbohydrate ligand for vascular E-selectin; recognizes sialyl Lewis x and sialyl Lewis a and other carbohydrate ligands for E-selectin, and E-selectin-binding epitopes of high endothelial venules
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PSGL-1 Antibody (HECA-452). This work is in progress.
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SEE ALSO...
PSGL-1 Antibody (HECA-452) is a rat monoclonal IgM antibody that detects PSGL-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). PSGL-1, also known as P-Selectin glycoprotein ligand or CD162, plays a crucial role in the immune response by mediating the adhesion of leukocytes to endothelial cells during inflammation. This interaction is vital for the recruitment of immune cells to sites of injury or infection, highlighting the importance of PSGL-1 in maintaining immune homeostasis. PSGL-1 is primarily located on the tips of microvilli of leukocytes, where a unique structure, characterized by a rich composition of serines, threonines, and prolines, allows for effective binding to selectins. Notably, PSGL-1 exists as a disulfide-linked homodimer and requires specific post-translational modifications, such as sialylation and fucosylation, to interact with P-Selectin and E-Selectin, underscoring the complexity of its function in cell adhesion and signaling. With a significant role in leukocyte trafficking and immune regulation, anti-PSGL-1 antibody (HECA-452) is an essential tool for researchers studying the mechanisms of inflammation and immune responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSGL-1 Antibody (HECA-452) | sc-53514 | 200 µg/ml | $322.00 | |||
PSGL-1 Antibody (HECA-452) FITC | sc-53514 FITC | 200 µg/ml | $336.00 | |||
PSGL-1 Antibody (HECA-452) PE | sc-53514 PE | 200 µg/ml | $349.00 |