Proteasome Inhibitor VII, Antiprotealide
Solicitud:
Proteasome Inhibitor VII, Antiprotealide is which inactivates the β5-subunit of the human 20S proteasome
Pureza:
≥95%
Peso Molecular:
275.7
Fórmula Molecular:
C12H18ClNO4
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
Proteasome Inhibitor VII, Antiprotealide is a cell-permeable, Omuralide-Salinosporamide hybrid that irreversibly inactivates the β5-subunit of the human 20S proteasome. The compound has shown to be ~2.5-fold more potent than Omuralide and is expected to exhibit comparable whole cell potency to Salinosporamide A.
References
1. Reddy, Leleti Rajender., et al., 2005. An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. Journal of the American Chemical Society. 127(25): 8974-6. PMID: 15969573
Estado de Materia
:
Solid
Solubilidad
:
Soluble in DMSO.
ALMACENAMIENTO
:
Store at -80° C
Punto de Fusión
:
194.33° C (Predicted)
Punto de ebullición
:
484.69° C at 760 mmHg (Predicted)
Densidad
:
1.31 g/cm3 (Predicted)
Indice de Refracción
:
n20D 1.53 (Predicted)
IC50
:
chymotrypsin-like activity of 20S proteasome: IC50 = 27 nM (rabbit ); trypsin-like activity of 20S proteasome: IC50 = 211 nM (rabbit); RPMI8226 cells: IC50 = 220 nM (human)
Valores de pK
:
pKa: 13.27 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID
:
SMILES
:
CC(C)[[email protected]@H]([[email protected]]12C(=O)O[[email protected]]1([[email protected]](C(=O)N2)CCCl)C)O
Descargar SDS (MSDS)
CERTIFICADO DE ANÁLISIS
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