PLEKHM3 Antibody (A-2): sc-393066
- PLEKHM3 Antibody (A-2) is a mouse monoclonal IgG2a κ PLEKHM3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-18 at the N-terminus of PLEKHM3 of human origin
- PLEKHM3 Antibody (A-2) is recommended for detection of PLEKHM3 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and avian
- Anti-PLEKHM3 Antibody (A-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PLEKHM3 Antibody (A-2) for WB and IHC(P) applications. These reagents are now offered in bundles with PLEKHM3 Antibody (A-2) (see ordering information below).
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PLEKHM3 Antibody (A-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects PLEKHM3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PLEKHM3 Antibody (A-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PLEKHM3, also known as pleckstrin homology domain containing, family M, member 3, is a 761 amino acid phosphoprotein that plays a crucial role in intracellular trafficking and signaling pathways. PLEKHM3 contains two pleckstrin homology (PH) domains and a phorbol-ester/DAG-type zinc finger, which are essential for binding to phosphoinositides and mediating protein-protein interactions. PLEKHM3 is predominantly located in the cytoplasm and is involved in the regulation of endosomal transport, which is vital for maintaining cellular homeostasis and facilitating the recycling of membrane proteins. PLEKHM3 is conserved across various species, including chimpanzees, dogs, cows, mice, rats, chickens, and zebrafish, and exists as three alternatively spliced isoforms that contribute to diverse functional roles. The gene encoding PLEKHM3 is located on human chromosome 2q33.3, a region that is significant due to its size and the number of genes harbored, making this area important for genetic studies and understanding evolutionary biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PLEKHM3 Antibody (A-2) References:
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
- Evidence for an ancestral alphoid domain on the long arm of human chromosome 2. | Avarello, R., et al. 1992. Hum Genet. 89: 247-9. PMID: 1587535
- Spectrum of ALMS1 variants and evaluation of genotype-phenotype correlations in Alström syndrome. | Marshall, JD., et al. 2007. Hum Mutat. 28: 1114-23. PMID: 17594715
- Compound heterozygous ABCA12 mutations including a novel nonsense mutation underlie harlequin ichthyosis. | Akiyama, M., et al. 2007. Dermatology. 215: 155-9. PMID: 17684380
- Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. | Virtanen, C., et al. 2009. J Biol Chem. 284: 1636-43. PMID: 19028694
- Origin of human chromosome 2: an ancestral telomere-telomere fusion. | IJdo, JW., et al. 1991. Proc Natl Acad Sci U S A. 88: 9051-5. PMID: 1924367
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PLEKHM3 Antibody (A-2) | sc-393066 | 200 µg/ml | $322.00 | |||
PLEKHM3 Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-526218 | 200 µg Ab; 10 µg BP | $361.00 | |||
PLEKHM3 Antibody (A-2): m-IgG2a BP-HRP Bundle | sc-546532 | 200 µg Ab; 10 µg BP | $361.00 | |||
PLEKHM3 Antibody (A-2) AC | sc-393066 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PLEKHM3 Antibody (A-2) HRP | sc-393066 HRP | 200 µg/ml | $322.00 | |||
PLEKHM3 Antibody (A-2) FITC | sc-393066 FITC | 200 µg/ml | $336.00 | |||
PLEKHM3 Antibody (A-2) PE | sc-393066 PE | 200 µg/ml | $349.00 | |||
PLEKHM3 Antibody (A-2) Alexa Fluor® 488 | sc-393066 AF488 | 200 µg/ml | $364.00 | |||
PLEKHM3 Antibody (A-2) Alexa Fluor® 546 | sc-393066 AF546 | 200 µg/ml | $364.00 | |||
PLEKHM3 Antibody (A-2) Alexa Fluor® 594 | sc-393066 AF594 | 200 µg/ml | $364.00 | |||
PLEKHM3 Antibody (A-2) Alexa Fluor® 647 | sc-393066 AF647 | 200 µg/ml | $364.00 | |||
PLEKHM3 Antibody (A-2) Alexa Fluor® 680 | sc-393066 AF680 | 200 µg/ml | $364.00 | |||
PLEKHM3 Antibody (A-2) Alexa Fluor® 790 | sc-393066 AF790 | 200 µg/ml | $364.00 | |||
PLEKHM3 (A-2) Neutralizing Peptide | sc-393066 P | 100 µg/0.5 ml | $69.00 |