phostensin Antibody (B-11): sc-376833

Phostensin Antibody (B-11) is a mouse monoclonal IgG2b antibody that detects phostensin in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Phostensin, also known as KIAA1949, is a 613 amino acid protein that plays a crucial role in cellular regulation by acting as a regulatory subunit that targets protein phosphatase 1 (PP1) to F-Actin within the cytoskeleton. This targeting is vital for maintaining the dynamic structure of the cytoskeleton, which is essential for various cellular processes, including cell shape, motility, and division. The interaction between phostensin and PP1 is particularly important as PP1 facilitates the dephosphorylation of specific substrates, thereby influencing cellular signaling pathways that govern cell growth and apoptosis. Phostensin is predominantly expressed in tissues such as the spleen, ovary, lung, and liver, and phostensin′s two isoforms, resulting from alternative splicing, may have distinct regulatory roles, further underscoring the complexity of its function in cellular homeostasis. Anti-phostensin antibody (B-11) is an invaluable tool for researchers investigating the intricate mechanisms of protein regulation and cytoskeletal dynamics in mouse models.

The preferred phostensin antibody is phostensin Antibody (H-9): sc-376816.