PHA 767491 hydrochloride CAS: 942425-68-5
MF: C12H11N3O•HCl
MW: 249.7
A potent, ATP-competitive dual cdc7/cdk9 inhibitor.

PHA 767491 hydrochloride (CAS 942425-68-5)

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Solicitud: PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor
Número de CAS: 942425-68-5
Pureza: >99%
Peso Molecular: 249.7
Fórmula Molecular: C12H11N3O•HCl
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
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PHA 767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. PHA 767491 hydrochloride induces apoptosis in a p53-independent manner, and inhibits cell proliferation in a variety of human cell lines (IC50 ~ 0.86 - 5.87 μM). The compound also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2) (IC50 = 171 nM).


References

Anderson et al (2007) Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) J.Med.Chem. 50 2647. Jackson (2008) Stopping replication, at the beginning. Nature Chem.Biol. 4 331. Montagnoli et al (2008) A cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumour activity. Nature Chem.Biol. 4 357.

Estado de Materia :
Solid
Solubilidad :
Soluble to 100 mM in Water and to 100 mM in DMSO
ALMACENAMIENTO :
Desiccate at room temperature
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
SMILES :
C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3.Cl

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PHA 767491 hydrochloride (CAS 942425-68-5)  Menciones del Producto

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PMID: # 28630312  2017. Proc. Natl. Acad. Sci. U.S.A. 114: E5352-E5361.

PMID: # 27587400  Xu, X. et al. 2016. J. Biol. Chem. 291: 22544-22558.

PMID: # 25737283  Sansam, CG. et al. 2015. Genes Dev. 29: 555-66.

Citaciones 1 a 3 de un total de 3
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