PAR4 Antibody (3G9H7): sc-130078
- PAR4 Antibody (3G9H7) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-330 of PAR4 of human origin
- recommended for detection of PAR4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See PAR4 (A-10): sc-1666 for PAR4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG1 BP-HRP is the preferred secondary detection reagent for PAR4 Antibody (3G9H7) for WB and IHC(P) applications. This reagent is now offered in a bundle with PAR4 Antibody (3G9H7) (see ordering information below).
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PAR4 Antibody (3G9H7) is a mouse monoclonal IgG1 antibody that detects PAR4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PAR4, or prostate apoptosis response 4, plays a crucial role in the regulation of apoptosis, a process essential for normal tissue homeostasis and development. PAR4 is specifically expressed in cells undergoing apoptosis and is not induced by growth factor stimulation, oxidative stress, necrosis, or growth arrest, highlighting its unique function in programmed cell death. The PAR4 gene encodes a protein that features a putative nuclear localization signal and a carboxy-terminal leucine zipper, which are important for its function in the nucleus and may facilitate interactions with other proteins involved in apoptotic signaling pathways. Understanding the role of PAR4 in apoptosis is vital, as dysregulation of this process can lead to various diseases, including cancer. Anti-PAR4 antibody (3G9H7) is an invaluable tool for researchers studying the mechanisms of apoptosis and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PAR4 Antibody (3G9H7) References:
- Quantitative proteomics analysis reveals similar release profiles following specific PAR-1 or PAR-4 stimulation of platelets. | van Holten, TC., et al. 2014. Cardiovasc Res. 103: 140-6. PMID: 24776597
- PAR-4: a possible new target for age-related disease. | Qinan, W., et al. 2014. Expert Opin Ther Targets. 18: 917-27. PMID: 24890982
- Cancer-selective apoptosis by tumor suppressor par-4. | Hebbar, N., et al. 2014. Adv Exp Med Biol. 818: 155-66. PMID: 25001535
- Stimulation of PAR-1 or PAR-4 promotes similar pattern of VEGF and endostatin release and pro-angiogenic responses mediated by human platelets. | Etulain, J., et al. 2015. Platelets. 26: 799-804. PMID: 26082997
- A journey beyond apoptosis: new enigma of controlling metastasis by pro-apoptotic Par-4. | Rasool, RU., et al. 2016. Clin Exp Metastasis. 33: 757-764. PMID: 27568374
- Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy. | Rwibasira Rudinga, G., et al. 2018. Int J Mol Sci. 19: PMID: 29443899
- Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity. | Araujo, N., et al. 2022. Front Oncol. 12: 860446. PMID: 35425699
- Targeting PAR4 to Reduce Atherosclerosis. | Barrett, TJ. 2023. Arterioscler Thromb Vasc Biol. 43: 2179-2182. PMID: 37767705
- Elevated protease-activated receptor 4 (PAR4) gene expression in Alzheimer's disease predicts cognitive decline. | Winfree, RL., et al. 2024. Neurobiol Aging. 140: 93-101. PMID: 38761538
- Tumor suppressor Par-4 activates autophagy-dependent ferroptosis. | Subburayan, K., et al. 2024. Commun Biol. 7: 732. PMID: 38886572
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAR4 Antibody (3G9H7) | sc-130078 | 200 µg/ml | $322.00 | |||
PAR4 Antibody (3G9H7): m-IgG1 BP-HRP Bundle | sc-542635 | 200 µg Ab; 20 µg BP | $361.00 |