p-PKC delta Antibody (F-7): sc-365969

p-PKC δ Antibody (F-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects Thr 507 phosphorylated PKC δ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). p-PKC δ (F-7) antibody is available in a non-conjugated form, providing flexibility for various experimental setups. The protein kinase C (PKC) family, to which PKC δ belongs, is integral to numerous cellular processes, including cell growth, differentiation, and apoptosis. PKC δ is particularly important in the regulation of apoptosis and cell survival, acting as a mediator of signaling pathways that respond to stress and growth factors. PKC δ activation is influenced by diacylglycerols and phorbol esters, which bind and promote catalytic activity. PKC δ undergoes post-translational modifications, including phosphorylation, which can modulate activity and interactions with other proteins. Phosphorylation of specific residues can enhance PKC δ′s role in signaling cascades that control cell fate decisions, making PKC δ a critical target for research in cancer and other diseases. Understanding PKC δ dynamics and interactions can provide insights into therapeutic strategies aimed at modulating function in various pathological conditions.

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p-PKC delta Antibody (F-7) References:

1. Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils.  |  Kilpatrick, LE., et al. 2000. Am J Physiol Cell Physiol. 279: C2011-8. PMID: 11078718
2. Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation.  |  Tapia, JA., et al. 2002. Biochim Biophys Acta. 1593: 99-113. PMID: 12431789
3. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.  |  Gan, X., et al. 2012. Nat Cell Biol. 14: 686-96. PMID: 22609986
4. Activation of PKC-δ in HTLV-1-infected T cells.  |  Mori, N., et al. 2015. Int J Oncol. 46: 1609-18. PMID: 25625567
5. PKC-δ/PKC-α activity balance regulates the lethal effects of cisplatin.  |  Muscella, A., et al. 2015. Biochem Pharmacol. 98: 29-40. PMID: 26300055
6. Aldosterone rapidly activates p-PKC delta and GPR30 but suppresses p-PKC epsilon protein levels in rat kidney.  |  Eiam-Ong, S., et al. 2019. Endocr Regul. 53: 154-164. PMID: 31517630
7. Moracin D induces apoptosis in prostate cancer cells via activation of PPAR gamma/PKC delta and inhibition of PKC alpha.  |  Yoon, JS., et al. 2021. Phytother Res. 35: 6944-6953. PMID: 34709688
8. Class I HDAC inhibitors attenuate dexamethasone-induced muscle atrophy via increased protein kinase C (PKC) delta phosphorylation.  |  Habibian, JS., et al. 2023. Cell Signal. 110: 110815. PMID: 37478958
9. CDDO regulates central and peripheral sensitization to attenuate post-herpetic neuralgia by targeting TRPV1/PKC-δ/p-Akt signals.  |  Lu, CC., et al. 2024. J Cell Mol Med. 28: e18131. PMID: 38426931
10. Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice.  |  Wang, D., et al. 2024. Cell Death Discov. 10: 314. PMID: 38972937

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-PKC delta Antibody (F-7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-p-PKC delta Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-PKC delta Antibody (F-7) Specifications

Alternate Product Name: PRKCD

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: Thr 507

Epitope Target: PKC δ

Epitope Species: human

Product Reactivity/Detection: Thr 507 phosphorylated PKC δ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for p-PKC delta Antibody (F-7): P: Blocking Peptide

The preferred PKC delta antibody is PKC delta Antibody (G-9): sc-8402.