p-p120 Antibody (pS288.6A): sc-293006

p-p120 Antibody (pS288.6A) is a mouse monoclonal IgG1 antibody that detects p120 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). anti-p120 antibody (pS288.6A) specifically recognizes the phosphorylated form of p120, a critical protein that plays a significant role in cellular adhesion and signaling pathways. Located in the cytoplasm, nucleus, and cell membrane, p120 is essential for mediating interactions between cadherins and catenins, which are vital for maintaining tissue integrity and regulating cell behavior. The phosphorylation of p120 at serine 288 influences p120′s interactions with other signaling molecules and can modulate its role in receptor signaling pathways, including those activated by epidermal growth factor, platelet-derived growth factor, and colony-stimulating factor-1. Additionally, p120 exists in multiple isoforms due to alternative splicing, which allows for diverse functional roles in various cellular contexts. p120 monoclonal antibody (pS288.6A) enables researchers to gain insights into the regulatory mechanisms of p120 phosphorylation and its implications in cellular processes, making p120 (pS288.6A) antibody a valuable tool for studying cell adhesion and signaling dynamics in health and disease.

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p-p120 Antibody (pS288.6A) References:

1. Cell adhesion properties and effects on receptor-mediated insulin endocytosis are independent properties of pp120, a substrate of the insulin receptor tyrosine kinase.  |  Soni, P., et al. 1999. Mol Cell Biol Res Commun. 1: 102-8. PMID: 10356358
2. Comparison of the intracellular trafficking of two alternatively spliced isoforms of pp120, a substrate of the insulin receptor tyrosine kinase.  |  Choice, CV., et al. 1999. J Cell Biochem. 76: 133-42. PMID: 10581007
3. Serine and threonine phospho-specific antibodies to p120-catenin.  |  Xia, X., et al. 2004. Hybrid Hybridomics. 23: 343-51. PMID: 15684660
4. PP120. Hydatidiform mole as a cause of eclampsia in the first trimester: A case report.  |  Ottanelli, S., et al. 2012. Pregnancy Hypertens. 2: 304. PMID: 26105442
5. The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.  |  Kim, L. and Wong, TW. 1995. Mol Cell Biol. 15: 4553-61. PMID: 7623846
6. Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase.  |  Najjar, SM., et al. 1995. Biochemistry. 34: 9341-9. PMID: 7626603
7. Molecular cloning of pp120/ECTO-ATPase, an endogenous substrate of the insulin receptor kinase.  |  Najjar, SM., et al. 1993. Adv Exp Med Biol. 343: 169-74. PMID: 8184737
8. Cloning and characterization of a functional promoter of the rat pp120 gene, encoding a substrate of the insulin receptor tyrosine kinase.  |  Najjar, SM., et al. 1996. J Biol Chem. 271: 8809-17. PMID: 8621519
9. Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5.  |  Dennehy, KM., et al. 1997. Eur J Immunol. 27: 679-86. PMID: 9079809
10. Effect of pp120 on receptor-mediated insulin endocytosis is regulated by the juxtamembrane domain of the insulin receptor.  |  Najjar, SM., et al. 1998. J Biol Chem. 273: 12923-8. PMID: 9582324

The preferred p120 antibody is p120 Antibody (15D2): sc-23872.