oligophrenin-1 Antibody (E-4): sc-376319
- oligophrenin-1 Antibody (E-4) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 703-802 mapping at the C-terminus of oligophrenin-1 of human origin
- recommended for detection of oligophrenin-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for oligophrenin-1 Antibody (E-4) for WB applications. These reagents are now offered in bundles with oligophrenin-1 Antibody (E-4) (see ordering information below).
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Oligophrenin-1 Antibody (E-4) is a mouse monoclonal IgG2b antibody that detects oligophrenin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Oligophrenin-1 plays a crucial role as a RhoGAP protein, stimulating the GTP hydrolysis of Rho subfamily members, which is essential for various cellular processes including cell migration, morphogenesis, and axon outgrowth. Anti-oligophrenin-1 antibody (E-4) influences the dynamics of the cytoskeleton and cellular signaling pathways that are vital for proper neuronal connectivity and plasticity. By facilitating the hydrolysis of GTP, oligophrenin-1 helps maintain the balance between active and inactive Rho proteins, thereby ensuring that cellular responses to external stimuli are appropriately modulated. Oligophrenin-1 (E-4) antibody is an invaluable tool for researchers studying the intricate mechanisms of cell signaling and development, providing insights into the roles of Rho GTPases in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
oligophrenin-1 Antibody (E-4) References:
- Oligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasia. | Bergmann, C., et al. 2003. Brain. 126: 1537-44. PMID: 12805098
- Mutations in the oligophrenin-1 gene (OPHN1) cause X linked congenital cerebellar hypoplasia. | Philip, N., et al. 2003. J Med Genet. 40: 441-6. PMID: 12807966
- Oligophrenin-1 (Ophn1) is expressed in mouse retinal vessels. | Sel, S., et al. 2012. Gene Expr Patterns. 12: 63-7. PMID: 22119667
- Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development. | Barresi, S., et al. 2014. PLoS One. 9: e91351. PMID: 24637888
- Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer. | Goto, K., et al. 2014. Pathobiology. 81: 190-8. PMID: 25170626
- Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells. | Houy, S., et al. 2015. J Neurosci. 35: 11045-55. PMID: 26245966
- The intellectual disability protein Oligophrenin-1 controls astrocyte morphology and migration. | Pillet, LE., et al. 2020. Glia. 68: 1729-1742. PMID: 32073702
- Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex. | Wang, M., et al. 2021. Neuron. 109: 1636-1656.e8. PMID: 33831348
- Androgen deprivation‑induced OPHN1 amplification promotes castration‑resistant prostate cancer. | Liu, J., et al. 2022. Oncol Rep. 47: PMID: 34738630
- Circ-OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR-558/THBS2 axis. | Li, Y., et al. 2022. Drug Dev Res. 83: 1034-1046. PMID: 35277867
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
oligophrenin-1 Antibody (E-4) | sc-376319 | 200 µg/ml | $322.00 | |||
oligophrenin-1 Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-535482 | 200 µg Ab; 40 µg BP | $361.00 | |||
oligophrenin-1 Antibody (E-4): m-IgG2b BP-HRP Bundle | sc-549427 | 200 µg Ab; 10 µg BP | $361.00 |