NTNCB hydrochloride is a potent, selective, competitive non-peptidic NPY5-R antagonist. Ki values are 8.0 and 16032 nM at human recombinant NPY5-R and NPY1-R respectively. NTNCB hydrochloride potently antagonizes NPY (neuropeptide Y) inhibition of forskolin-stimulated cAMP. NTNCB hydrochloride shows some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).
Islam et al (2002) Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg.Med.Chem.Lett. 12 1767.
Estado de Materia
Soluble to 100 mM in DMSO
Store at room temperature
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
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