Molecular structure of NOR-3, CAS Number: 163180-49-2
NOR-3 (CAS 163180-49-2)
Alternate Names:
FK 409; (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
Application:
NOR-3 is a cell-permeable NO donor
CAS Number:
163180-49-2
Purity:
≥98%
Molecular Weight:
215.21
Molecular Formula:
C8H13N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NOR-3 is a cell-permeable, non-thiol, nitric oxide (NO) donor that can spontaneously release NO in a rate controlled manner (half-life in PBS, pH 7.4 is 30 minutes at 37°C) generating biologically inactive by-products. NOR-3 spontaneously releases NO intra- and extracellularly and activates intracellular soluble guanylate cyclase, leading to an increase in cGMP level and subsequent vascular relaxation and inhibition of platelet aggregation. NORs release NO at a steady rate, although the mechanism of release is not yet known.
NOR-3 (CAS 163180-49-2) References
- Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid. | Percival, MD., et al. 1999. Biochemistry. 38: 13574-83. PMID: 10521264
- Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. | Tashima, K., et al. 2000. Life Sci. 67: 1639-52. PMID: 10983857
- Effects of sulfhydryl reagents on nitric oxide release from a nitric oxide donor NOR 3 in the presence of rat hepatocytes. | Nomura, H., et al. 2000. Pharmacol Toxicol. 87: 246-8. PMID: 11129506
- [Vasodilatory action of FK 409 on bovine retinal arteries--analysis by a microvessel perfusion system]. | Sugimoto, K., et al. 2002. Nippon Ganka Gakkai Zasshi. 106: 338-42. PMID: 12138695
- Nitric oxide of the supraoptic nucleus influences the salivary secretion, sodium renal excretion, urinary volume and arterial blood pressure induced by pilocarpine. | Saad, WA., et al. 2004. Life Sci. 74: 1593-603. PMID: 14738904
- Interaction between supraoptic nucleus and septal area in the control of water, sodium intake and arterial blood pressure induced by injection of angiotensin II. | Saad, WA., et al. 2004. Pharmacol Biochem Behav. 77: 667-74. PMID: 15099911
- Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats. | Abrão Saad, W., et al. 2004. Life Sci. 75: 685-97. PMID: 15172178
- FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. | Man, K., et al. 2004. Ann Surg. 240: 159-68. PMID: 15213632
- Comparison of the effects of the novel vasodilator FK409 with those of nitroglycerin in isolated coronary artery of the dog. | Yamada, H., et al. 1991. Br J Pharmacol. 103: 1713-8. PMID: 1681975
- Characteristics of the vasorelaxing action of (3E)-4-ethyl-2-hydroximino-5-nitro-3-hexamide FK409, a new vasodilator isolated from microbial sources, in isolated rabbit arteries. | Shibata, S., et al. 1991. J Cardiovasc Pharmacol. 17: 508-18. PMID: 1711615
- FK409, a novel vasodilator isolated from the acid-treated fermentation broth of Streptomyces griseosporeus. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. | Hino, M., et al. 1989. J Antibiot (Tokyo). 42: 1578-83. PMID: 2584140
- Antiplatelet activities of FK409, a new spontaneous NO releaser. | Kita, Y., et al. 1994. Br J Pharmacol. 113: 385-8. PMID: 7834188
- Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. | Kita, Y., et al. 1994. Eur J Pharmacol. 257: 123-30. PMID: 8082692
- Coronary and systemic hemodynamic effects of the putative nitric oxide donor, FK 409, in comparison with nitroglycerin in conscious and anesthetized dogs. | Drieu la Rochelle, C., et al. 1995. J Cardiovasc Pharmacol. 26: 555-63. PMID: 8569215
- Central and peripheral mechanisms involved in hypertension induced by chronic inhibition of nitric oxide synthase in rats. | Liu, Y., et al. 1998. J Hypertens. 16: 1165-73. PMID: 9794721
Activator of:
Enzyme, and Guanylate Cyclases.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOR-3, 5 mg | sc-202738 | 5 mg | $133.00 | |||
NOR-3, 10 mg | sc-202738A | 10 mg | $295.00 |