Anti-Munc13-1/2/3 Anticuerpo 32 es un monoclonal de ratón IgG1 (kappa light chain) Munc13-1/2/3 Anticuerpo proporcionado como 200 µg/ml
producido contra los amino ácidos 621-834 de Munc13-1 de origen rat
recomendado para detectarMunc13-1, Munc13-2 and Munc13-3 de mouse y rat origen, mediante WB, IP y IF
Contacte con nosotros para recibir GRATIS 10 µg de muestra de Munc13-1/2/3 (32): sc-136182.
m-IgGκ BP-HRP is the preferred secondary detection reagent for Munc13-1/2/3 Antibody (32) for WB applications. This reagent is now offered in a bundle with Munc13-1/2/3 Antibody (32) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Munc13-1/2/3 Antibody (32) is a high quality monoclonal Munc13-1/2/3 antibody (also designated Munc13-1/2/3 antibody) suitable for the detection of the Munc13-1/2/3 protein of mouse and rat origin. Munc13-1/2/3 Antibody (32) is available as the non-conjugated anti-Munc13-1/2/3 antibody. Munc13 proteins (Munc13-1, Munc13-2, and Munc13-3) make up a family of highly homologous synaptic molecules that bind Syntaxin, an essential mediator of neurotransmitter release. Munc13 proteins contain phorbol ester binding C1- and C2-domains, which are regulatory domains for Ca2+, phospholipids and diacylglycerol. Munc13 proteins are primarily expressed by neurons, except for a ubiquitously expressed Munc13-2 splice variant. Munc13-1 is expressed by most neurons; it interacts with the N-terminal of Doc2α, which is concentrated on the synaptic vesicle. Munc13-1 also interacts directly with msec7-1 to co-localize the two proteins at the active zone, a presynaptic, subcellular compartment with extremely high membrane turnover. Munc13-1 is essential for synaptic vesicle maturation and plays a role in the central priming function in synaptic vesicle exocytosis from glutamatergic synapses. Munc13-1 is concentrated in presynaptic terminals. Munc13-2 is expressed in rostral regions, whereas Munc13-3 is expressed primarily in the cerebellum.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.